Department of General Surgery, The First Affiliated Hospital of Clinical Medicine of Guangdong Pharmaceutical University, Guangzhou, China.
Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Heart Surg Forum. 2021 Dec 14;24(6):E1015-E1017. doi: 10.1532/hsf.4169.
To explore the value of metagenomics next-generation sequencing (mNGS) for deep sternal wound infection (DSWI) diagnosis.
mNGS was used to diagnose DSWI after cardiac transplantation; DSWI was treated with surgical debridement, wound care, and antibiotic therapy guided by mNGS.
Coinfection of methicillin-resistant Staphylococcus aureus (MRSA) and cytomegalovirus (CMV) was detected in this patient. The infection was controlled and the wound healed successfully with the specific medicine based on mNGS results for 3 weeks.
mNGS is effective to achieve precise, individualized, and rapid treatment for wound infection.
探索宏基因组下一代测序（mNGS）在诊断深部胸骨伤口感染（DSWI）中的价值。
mNGS 用于诊断心脏移植后的 DSWI；mNGS 指导下采用手术清创、伤口护理和抗生素治疗来治疗 DSWI。
该患者检测到耐甲氧西林金黄色葡萄球菌（MRSA）和巨细胞病毒（CMV）的合并感染。经过 3 周基于 mNGS 结果的特定药物治疗，感染得到控制，伤口愈合良好。
mNGS 可有效实现对伤口感染的精确、个体化和快速治疗。
