圣马力诺及其在美国的一级亲属中的胃癌。胃镜活检作为一种流行病学工具。

Gastric cancer in San Marinese and their first degree relatives in San Marino and the United States. Gastroscopic biopsy as an epidemiological tool.

作者信息

Schuman B M, Salerno-Mele P, Ghironzi G, Jackson C E, Ma C K, Spigolon G

出版信息

Gastrointest Endosc. 1987 Jun;33(3):224-6. doi: 10.1016/s0016-5107(87)71563-6.

Abstract

The Republic of San Marino, a small, 23-square mile, independent country near the Adriatic Coast within Italy, has been noted to have a high incidence of gastric cancer in its 22,000 population (9% of all deaths from 1969-1983 with 33% of all cancer deaths attributed to gastric cancer). Gastroscopic biopsy studies on 284 first degree relatives of San Marinese gastric cancer patients in the Republic of San Marino and in Detroit, where 2,000-2,500 San Marinese reside, have allowed detection of six gastric malignancies. Intestinal metaplasia of gastric mucosa was found in 16 (52%) of 31 Detroit first degree relatives and 51 (36%) of 143 San Marino first degree relatives. Gastroscopy provides an important tool not only for the early detection of gastric cancer in populations of high risk (such as that of San Marino), but also for providing clues to the genetic and environmental factors in gastric neoplasia.

摘要

圣马力诺共和国是一个面积仅23平方英里的小国，位于意大利境内的亚得里亚海沿岸。据记载，在其2.2万人口中，胃癌发病率很高（在1969年至1983年期间，胃癌死亡人数占总死亡人数的9%，所有癌症死亡人数中有33%归因于胃癌）。对圣马力诺共和国和底特律（有2000至2500名圣马力诺人居住）的284名圣马力诺胃癌患者的一级亲属进行了胃镜活检研究，已检测出6例胃恶性肿瘤。在底特律的31名一级亲属中，有16名（52%）发现胃黏膜肠化生；在圣马力诺的143名一级亲属中，有51名（36%）发现胃黏膜肠化生。胃镜检查不仅为高危人群（如圣马力诺人群）早期发现胃癌提供了重要工具，也为了解胃肿瘤形成中的遗传和环境因素提供了线索。