Zhang Yuan, Lu Wei, Zhao Qing, Chen Jindong, Wang Tiancong, Ji Jun
Department of Orthodontics, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, People's Republic of China.
Nanjing Key Laboratory, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, People's Republic of China.
Dev Dyn. 2022 May;251(5):748-758. doi: 10.1002/dvdy.449. Epub 2022 Jan 5.
SHP2, encoded by the PTPN11 gene, participates in multiple cell functions including cell proliferation, movement, and differentiation. PTPN11 loss-of-function and gain-of-function mutations are both associated with diseases, such as Noonan syndrome, whose manifestations include bone defects, suggesting a crucial role for SHP2 in the skeleton. However, the exact mechanisms by which SHP2 regulates bone development remain unclear. This review focuses on the current understanding of the regulation of SHP2 and highlights the vital roles of SHP2 in skeletal development, especially its roles in ossification. Overall, a better understanding of the functions of SHP2 in ossification will provide a new avenue to treat-related skeletal diseases.
由PTPN11基因编码的SHP2参与多种细胞功能，包括细胞增殖、运动和分化。PTPN11功能丧失和功能获得性突变均与疾病相关，如努南综合征，其表现包括骨骼缺陷，提示SHP2在骨骼中起关键作用。然而，SHP2调节骨骼发育的确切机制仍不清楚。本综述重点关注目前对SHP2调节的理解，并强调SHP2在骨骼发育中的重要作用，特别是其在骨化中的作用。总体而言，更好地理解SHP2在骨化中的功能将为治疗相关骨骼疾病提供新途径。
