Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
School of Environmental Science and Engineering, Shaanxi University of Science and Technology, Xian 710021, China.
ACS Nano. 2022 Jan 25;16(1):974-983. doi: 10.1021/acsnano.1c08580. Epub 2021 Dec 28.
Oxygen consumption but hypoxic tumor environment has been considered as the major obstacle in photodynamic therapy. Although oxygen-supplied strategies have been reported extensively, they still suffer from the complicated system and unsatisfied PDT efficiency. Herein, one-component layered nickel silicate nanoplatforms (LNS NPs) are successfully synthesized using natural vermiculite as the silica source, which can simultaneously supply oxygen (O) and generate superoxide radicals (O) under near-infrared irradiation. The appropriate electron band structure endows LNS NPs with attractive optical properties, where the bandgap edges determine the performance of redox activity and spectral response characteristic. Evidenced by both and investigations, LNS NPs can generate sufficient superoxide radicals under 660 nm laser irradiation to induce tumor cell apoptosis even in a severe hypoxic environment, which benefits from self-supplied oxygen. Besides, the photoacoustic oxy-hem imaging and histologic assay further demonstrated that the generated oxygen can relieve the inherent intratumoral hypoxia. Therefore, LNS NPs not only serve as superoxide radical generator but also produce oxygen to modulate hypoxia, suggesting that it can be used for superoxide radical-mediated photodynamic therapy with enhanced antitumor effect.
耗氧量和缺氧肿瘤微环境一直被认为是光动力疗法的主要障碍。尽管已经广泛报道了供氧策略，但它们仍然存在系统复杂和光动力治疗效率不高的问题。本文中，我们成功地以天然蛭石为硅源合成了一种单一组分层镍硅酸盐纳米平台（LNS NPs），它可以在近红外光照射下同时供氧和产生超氧自由基（O）。适当的电子能带结构赋予了 LNS NPs 吸引人的光学性质，其中带隙边缘决定了氧化还原活性和光谱响应特性的性能。通过 和 研究表明，LNS NPs 在 660nm 激光照射下可以产生足够的超氧自由基，即使在严重缺氧的环境下也能诱导肿瘤细胞凋亡，这得益于自供氧。此外，光声氧合血成像和组织学分析进一步表明，生成的氧气可以缓解肿瘤内固有的缺氧。因此，LNS NPs 不仅可以作为超氧自由基的产生剂，还可以产生氧气来调节缺氧，表明它可用于超氧自由基介导的光动力治疗，增强抗肿瘤效果。
