Meng X X, Liu J, Li J X, Yang N, Zhou J S, Cui L Y
Department of Clinical Laboratory, Peking University Third Hospital,Beijing 100191,China.
Department of Clinical Laboratory, Rizhao Hospital of Traditional Chinese Medicine,Rizhao 276800,China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2021 Dec 6;55(12):1456-1460. doi: 10.3760/cma.j.cn112150-20210704-00635.
The results of syphilis antibody screening in Peking University Third Hospital from 2016 to 2020 were analyzed,to explore the characteristics of sex, age and distribution of patients with positive syphilis antibody. A retrospective study was conducted to collect the results of syphilis antibody in outpatients and inpatients of Peking University Third Hospital from 2016 to 2020. Syphilis antibodies were screened in 626 528 patients aged 1-98 years, 4 232 were retested positive by TPPA test, including 2 132 males (50.4%) and 2 100 females (49.6%). Chemiluminescence immunoassay (CMIA) was used for syphilis antibody screening, and Treponema pallidum particle agglutination (TPPA) test was used for reexamination. SPSS20.0 data statistical analysis software was used to analyze the detection rate, age, sex, department and clinical diagnosis of patients with positive syphilis antibody by χ² test. Among 626 528 patients who were positive for treponema pallidum antibody screening, 4 232 were retested positive by TPPA test, accounting for 0.68% of the total number of patients tested. The number of syphilis tests increased year by year, however the positive detection rate decreased. The positive detection rate of syphilis antibody in 2020 decreased by 18.9% compared with 2016. The positive rate of syphilis antibody in male patients was higher than that in female patients, accounting for 0.80% and 0.59% of the total number of patients tested respectively. The positive rate of syphilis antibody of different genders increased with age, the total positive rate of 0-20, 21-40, 41-60, 61-80,>80 years old were 0.15%, 0.45%, 0.95%, 1.07% and 1.41%, respectively. While the increase rate of males was higher than that of females. The positive rate of male over 80 years old was 18.13 times of the group of 0-20 years old, and 5.54 times in women. The top 6 departments with positive syphilis antibody detection rate were emergency department, oncology department, respiratory department, geriatrics department, endocrinology department and neurology department, and the positive rates were 1.79% (104/5 810),1.46% (55/3 767),1.20% (74/6 167),1.20% (22/1 833),1.10% (32/2 909),1.09% (94/8 624), respectively. From the analysis of clinical diagnosis, the proportion of positive syphilis antibody in infertile patients (0.64%, 672/104 911) was higher than that in naturally conceived patients (0.10%, 24/23 969). From 2016 to 2020, the positive detection rate of syphilis antibody in Peking University Third Hospital decreased year by year. However, the positive detection rate increased with the age of patients. The positive rate of syphilis antibody in male was higher than that in female. The positive rate of syphilis antibody in pregnant women was lower than that in infertile patients.
分析北京大学第三医院2016年至2020年梅毒抗体筛查结果，以探讨梅毒抗体阳性患者的性别、年龄及分布特征。采用回顾性研究方法，收集北京大学第三医院2016年至2020年门诊及住院患者的梅毒抗体检测结果。对626528例年龄在1 - 98岁的患者进行梅毒抗体筛查，其中4232例经梅毒螺旋体颗粒凝集试验（TPPA）复测为阳性，包括男性2132例（50.4%），女性2100例（49.6%）。梅毒抗体筛查采用化学发光免疫分析法（CMIA），复查采用梅毒螺旋体颗粒凝集试验（TPPA）。应用SPSS20.0数据统计分析软件，采用χ²检验分析梅毒抗体阳性患者的检出率、年龄、性别、科室及临床诊断情况。在626528例梅毒螺旋体抗体筛查阳性患者中，4232例经TPPA复测为阳性，占总检测人数的0.68%。梅毒检测数量逐年增加，但阳性检出率呈下降趋势。2020年梅毒抗体阳性检出率较2016年下降了18.9%。男性患者梅毒抗体阳性率高于女性患者，分别占总检测人数的0.80%和0.59%。不同性别的梅毒抗体阳性率随年龄增长而升高，0 - 20岁、21 - 40岁、41 - 60岁、61 - 80岁、>80岁的总阳性率分别为0.15%、0.45%、0.95%、1.07%和1.41%。男性上升幅度高于女性。80岁以上男性的阳性率是0 - 20岁组的18.13倍，女性为5.54倍。梅毒抗体检测阳性率排名前6的科室为急诊科、肿瘤科、呼吸科、老年科、内分泌科和神经内科，阳性率分别为1.79%（104/5810）、1.46%（55/3767）、1.20%（74/6167）、1.20%（22/1833）、1.10%（32/2909）、1.09%（94/8624）。从临床诊断分析，不孕患者梅毒抗体阳性比例（0.64%，672/104911）高于自然受孕患者（0.10%，24/23969）。2016年至2020年，北京大学第三医院梅毒抗体阳性检出率逐年下降。然而，阳性检出率随患者年龄增长而升高。男性梅毒抗体阳性率高于女性。孕妇梅毒抗体阳性率低于不孕患者。
