Fan X S, Shen L L, Hu R, He J X, Li Y T, Yuan H
Department of Clinical Laboratory, Beijing Anzhen Hospital, Beijing 100029, China.
Graduate School, Capital Medical University, Beijing 100069, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2021 Dec 6;55(12):1507-1512. doi: 10.3760/cma.j.cn112150-20210817-00801.
Atherosclerotic cardiovascular disease (ASCVD), a series of cardiovascular diseases based on atherosclerosis, has attracted more clinical attention. However, with the increase of population-based research results, the diagnostic value of traditional blood lipid parameters such as low density lipoprotein-cholesterol (LDL-C) is showing limitations. In recent years, a large number of studies have confirmed that small dense low-density lipoprotein cholesterol (sdLDL-C) has lower affinity with low-density lipoprotein receptor, longer circulation time and easier to penetrate arterial endothelium, so it has stronger atherogenic effect. Therefore, we summarize the common detection methods of sdLDL-C, the research progress of the correlation between sdLDL-C and ASCVD risk, as well as the intervention measures and influencing factors of sdLDL-C level, in order to deepen the clinician's understanding of the role of sdLDL-C in ASCVD and achieve the early prevention, early detection and early diagnosis of chronic atherosclerosis.
动脉粥样硬化性心血管疾病（ASCVD）是一系列基于动脉粥样硬化的心血管疾病，已引起更多临床关注。然而，随着基于人群的研究结果不断增加，传统血脂参数如低密度脂蛋白胆固醇（LDL-C）的诊断价值正显示出局限性。近年来，大量研究证实，小而密低密度脂蛋白胆固醇（sdLDL-C）与低密度脂蛋白受体的亲和力较低，循环时间较长，且更容易穿透动脉内皮，因此具有更强的致动脉粥样硬化作用。因此，我们总结了sdLDL-C的常见检测方法、sdLDL-C与ASCVD风险相关性的研究进展，以及sdLDL-C水平的干预措施和影响因素，以加深临床医生对sdLDL-C在ASCVD中作用的理解，实现慢性动脉粥样硬化的早期预防、早期发现和早期诊断。
