Sabithakala Thatituri, Reddy Chittireddy Venkata Ramana
Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, Hyderabad, India.
J Biomol Struct Dyn. 2023 Mar;41(4):1309-1321. doi: 10.1080/07391102.2021.2019121. Epub 2021 Dec 29.
A tridentate ligand(A), 2-(((6-chloro-1H-benzo[d]imidazol-2-yl)methyl)amino) aceticacid (Cl-BIGH) was synthesised by the Phillips condensation of 4-chlorobenzene-1,2-diamine and iminodiaceticacid in 1:2 molar ratio. Its Cu(II) mixed ligand complexes[Cu(II)-A-L] were obtained by involving other co-ligands(L): 2,2΄-bipyridine(L), 4,4΄-dimethyl-2,2΄-bipyridyl(L), 5,5΄-dimethyl-2,2΄-bipyridyl(L) and 1,10 phenanthroline(L). The complexes were characterized by elemental analysis, thermal analysis, molar conductance, magnetic moment measurements, X-ray diffraction, FTIR, UV-Visible, ESR spectroscopy, mass spectrometry and cyclic voltammetry. From the spectral and analytical data, the ternary complexes [Cu(Cl-BIGH)(L)]ClO were found to form in 1:1:1(Cu(II): Cl-BIGH: L) molar ratio. The geometry of the mixed-ligand complexes were found to be 5-coordinated square pyramidal or trigonal bipyramidal with polycrystalline natures. The DNA binding and cleaving abilities, antibacterial and the cytotoxicity of the complexes were explored. The molecular docking was used to predict the efficiency of binding of the metal complexes with COX- 2.Communicated by Ramaswamy H. Sarma.
通过使4-氯苯-1,2-二胺与亚氨基二乙酸以1:2的摩尔比进行菲利普斯缩合反应，合成了一种三齿配体（A），即2-(((6-氯-1H-苯并[d]咪唑-2-基)甲基)氨基)乙酸（Cl-BIGH）。通过引入其他共配体（L）：2,2′-联吡啶（L）、4,4′-二甲基-2,2′-联吡啶（L）、5,5′-二甲基-2,2′-联吡啶（L）和1,10-菲咯啉（L），得到了其铜（II）混合配体配合物[Cu（II）-A-L]。通过元素分析、热分析、摩尔电导率、磁矩测量、X射线衍射、傅里叶变换红外光谱、紫外-可见光谱、电子自旋共振光谱、质谱和循环伏安法对配合物进行了表征。从光谱和分析数据可知，三元配合物[Cu（Cl-BIGH）（L）]ClO以1:1:1（铜（II）：Cl-BIGH：L）的摩尔比形成。发现混合配体配合物的几何构型为5配位的四方锥或三角双锥，具有多晶性质。研究了配合物的DNA结合和切割能力、抗菌活性和细胞毒性。利用分子对接预测金属配合物与COX-2的结合效率。由拉马什瓦米·H·萨尔马通讯。
