Fortuny Joan, Plana Estel, Kaye James A
RTI Health Solutions, Barcelona, Catalonia, Spain.
RTI Health Solutions, Waltham, MA, USA.
Leuk Lymphoma. 2022 Feb;63(2):291-303. doi: 10.1080/10428194.2021.1992618. Epub 2021 Dec 29.
We conducted a case-control study of patients from the Clinical Practice Research Datalink in the United Kingdom to describe the trajectories of serum lipid in the years before a diagnosis of lymphoma. Study participants had at least one cholesterol measurement. Multilevel, multivariable linear longitudinal models were fit to examine the adjusted trajectories of serum lipid levels in the years before lymphoma diagnosis. Overall, 11,969 cases of non-Hodgkin lymphoma, 473 of Hodgkin lymphoma, and 61,894 controls were selected. Mean cholesterol levels in the years before the index date showed a more pronounced decrease in the 4 years before lymphoma diagnosis than in controls. Triglycerides levels were unrelated to case status. This research is the first to replicate the results of a similar study conducted in the United States while adjusting for more potential confounders. The newly described different behavior of cholesterol and triglycerides suggests a potential role of cholesterol in lymphomagenesis.
我们对来自英国临床实践研究数据链的患者进行了一项病例对照研究，以描述淋巴瘤诊断前数年血清脂质的变化轨迹。研究参与者至少进行过一次胆固醇测量。采用多水平、多变量线性纵向模型来检验淋巴瘤诊断前数年血清脂质水平的校正变化轨迹。总体而言，选取了11969例非霍奇金淋巴瘤病例、473例霍奇金淋巴瘤病例和61894例对照。在索引日期前数年，淋巴瘤诊断前4年的平均胆固醇水平下降比对照组更为明显。甘油三酯水平与病例状态无关。本研究首次在美国进行的一项类似研究的结果基础上进行了重复，并对更多潜在混杂因素进行了校正。新描述的胆固醇和甘油三酯的不同行为表明胆固醇在淋巴瘤发生中可能发挥作用。
