AlQahtani Sara H, AlOgaiel Areeb M, AlMosa Kowthar N, Alenazi Suha H, AlHasan Monira K, AlObaidan Reham H, Aldokheel Bayan D, AlSaleh Khalid, Arafah Maha, Ali Khan Imran, AlOtaiby Maram
Medicine, King Saud University, Riyadh, SAU.
General Surgery, King Abdullah Bin Abdulaziz University Hospital, Riyadh, SAU.
Cureus. 2021 Nov 22;13(11):e19816. doi: 10.7759/cureus.19816. eCollection 2021 Nov.
Objectives To estimate the proportion of positive epidermal growth factor receptor (EGFR) mutations among patients diagnosed with non-small cell lung carcinoma (NSCLC) and T790M at the King Khalid University Hospital (KKUH). Methods A retrospective cohort study that included all patients that were diagnosed with NSCLC from 2009 to 2017 at KKUH. Data obtained from both electronic and paper medical records and the following information were studied: age, gender, smoking, region, subtype of NSCLC, EGFR mutation test result, treatment, T790M mutation test (if required), comorbidities, metastasis. Statistical analysis was performed using the Statistical Package for the Social Sciences (SPSS, version 21.0; SPSS Inc., Chicago, IL, USA). Results Among 71 patients with NSCLC 18 cases were identified for EGFR positive mutation and only one case for T790M. Deletion mutation in exon 19 represented 50% of total cases. Moreover, it showed that it is more frequent in males and non-smokers with 61.1% (11) and 66.7% (12), respectively. Majority of the cases were above the age of 60 years by 61.1% (11). The mutations reported highest in those living in Najd with a 44.4% (8) and all the mutated cases were adenocarcinoma. There was no statistical significance in the association between EGFR mutation and disease variables. Conclusion Ultimately, we found that the frequency of EGFR and T790M mutations among NSCLC patients at KKUH from 2009 to 2017 was 25.4% and 1.4%, respectively. Moreover, this result was conspicuous among non-smokers.
目的 评估在哈立德国王大学医院（KKUH）被诊断为非小细胞肺癌（NSCLC）且伴有T790M突变的患者中表皮生长因子受体（EGFR）阳性突变的比例。方法 一项回顾性队列研究，纳入了2009年至2017年在KKUH被诊断为NSCLC的所有患者。从电子和纸质病历中获取数据，并研究以下信息：年龄、性别、吸烟情况、地区、NSCLC亚型、EGFR突变检测结果、治疗情况、T790M突变检测（如有需要）、合并症、转移情况。使用社会科学统计软件包（SPSS，版本21.0；SPSS公司，美国伊利诺伊州芝加哥）进行统计分析。结果 在71例NSCLC患者中，18例被鉴定为EGFR阳性突变，仅1例为T790M突变。19外显子缺失突变占总病例的50%。此外，该突变在男性和非吸烟者中更常见，分别为61.1%（11例）和66.7%（12例）。大多数病例年龄在60岁以上，占61.1%（11例）。在纳季德地区居住的患者中突变报告率最高，为44.4%（8例），且所有突变病例均为腺癌。EGFR突变与疾病变量之间的关联无统计学意义。结论 最终，我们发现2009年至2017年KKUH的NSCLC患者中EGFR和T790M突变的频率分别为25.4%和1.4%。此外，这一结果在非吸烟者中尤为明显。
