Huang Qiting, Liang Zelin, Li Junda, Bai Ying, He Jingwei, Lin Zhengmei
Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou 510055, China.
Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China.
ACS Omega. 2021 Dec 10;6(50):35057-35066. doi: 10.1021/acsomega.1c05825. eCollection 2021 Dec 21.
Resin composites that consist of polymeric resins and functional fillers are commonly used as restorative materials for dental caries. Various types of calcium phosphates (CaPs) are studied as remineralizing fillers in the formulation of dental resin composites, which are generally inhibitory to demineralization of teeth, but the performance of resin composites has not yet been investigated comprehensively with respect to the size of CaP particles. In this study, the same tricalcium phosphate (TCP) particles within two different size ranges, the as-received TCP particles (TCP) and those resulted from grinding (TCP-G), were tested to determine the size dependence of CaP fillers in dental resin composites. The buffering capability, mechanical properties, ion release, antibacterial performance, and remineralization effect of TCP/TCP-G-containing composites were experimentally characterized and compared against two other commercial dental materials. The integration of micrometer-sized TCP particles resulted in a similar buffering effect and Ca/PO release behaviors compared to the resin composite containing much smaller TCP-G particles. The flexural strength of the TCP-G resin composite was lower than that of the TCP composite after immersion in water for 30 days. However, the TCP-G composite facilitated crystal deposition toward better gap-closing performance at the dentin-composite interface. This study explored detailed insights about the size effect of CaP fillers, which is useful for the development of functional dental resin composites and their clinical translation.
由聚合树脂和功能性填料组成的树脂复合材料通常用作龋齿的修复材料。在牙科树脂复合材料配方中，人们研究了各种类型的磷酸钙（CaP）作为再矿化填料，这些填料通常对牙齿脱矿有抑制作用，但尚未就CaP颗粒大小对树脂复合材料性能进行全面研究。在本研究中，测试了两种不同尺寸范围内的相同磷酸三钙（TCP）颗粒，即原样接收的TCP颗粒（TCP）和研磨产生的TCP颗粒（TCP-G），以确定牙科树脂复合材料中CaP填料的尺寸依赖性。通过实验对含TCP/TCP-G复合材料的缓冲能力、机械性能、离子释放、抗菌性能和再矿化效果进行了表征，并与其他两种商用牙科材料进行了比较。与含有小得多的TCP-G颗粒的树脂复合材料相比，微米级TCP颗粒的加入产生了类似的缓冲效果和Ca/PO释放行为。在水中浸泡30天后，TCP-G树脂复合材料的弯曲强度低于TCP复合材料。然而，TCP-G复合材料促进了晶体沉积，在牙本质-复合材料界面具有更好的间隙闭合性能。本研究探索了关于CaP填料尺寸效应的详细见解，这对功能性牙科树脂复合材料的开发及其临床转化很有用。
