Fedosova Natalya U, Habeck Michael, Nissen Poul
Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Department of Molecular Biology and Genetics, Danish Research Institute of Translational Neuroscience - DANDRITE, Nordic EMBL Partnership for Molecular Medicine, Aarhus University, Aarhus, Denmark.
Compr Physiol. 2021 Dec 29;12(1):2659-2679. doi: 10.1002/cphy.c200018.
Na,K-ATPase is an ubiquitous enzyme actively transporting Na-ions out of the cell in exchange for K-ions, thereby maintaining their concentration gradients across the cell membrane. Since its discovery more than six decades ago the Na-pump has been studied extensively and its vital physiological role in essentially every cell has been established. This article aims at providing an overview of well-established biochemical properties with a focus on Na,K-ATPase isoforms, its transport mechanism and principle conformations, inhibitors, and insights gained from crystal structures. © 2021 American Physiological Society. Compr Physiol 11:1-21, 2021.
钠钾ATP酶是一种普遍存在的酶，它能将钠离子主动转运出细胞，以交换钾离子，从而维持它们在细胞膜两侧的浓度梯度。自六十多年前被发现以来，钠泵就得到了广泛研究，其在几乎每个细胞中的重要生理作用也已确立。本文旨在概述已被充分证实的生化特性，重点介绍钠钾ATP酶同工型、其转运机制和主要构象、抑制剂，以及从晶体结构中获得的见解。© 2021美国生理学会。《综合生理学》2021年第11卷：1 - 21页。
