家庭农药暴露与 MADRES 队列中婴儿粗大运动发育。
Household pesticide exposures and infant gross motor development in the MADRES cohort.
机构信息
Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Eisner Health, Los Angeles, California, USA.
出版信息
Paediatr Perinat Epidemiol. 2022 Mar;36(2):220-229. doi: 10.1111/ppe.12850. Epub 2021 Dec 29.
BACKGROUND
The development of motor skills in infancy is a vital neurodevelopmental milestone. Although previous studies have explored the neurotoxic effects of agricultural pesticides on infants' motor development, limited research has examined early postnatal household pesticide use on infants' motor development, particularly among urban communities.
OBJECTIVE
This study examined the association between early postnatal household pesticide use and infants' gross and fine motor development at 6 months of age.
METHODS
Questionnaires were administered via telephone to 296 mother-infant dyads in the Maternal and Developmental Risks from Environmental and Social Stressors (MADRES) pregnancy cohort. Early life household pesticide use was assessed via questionnaire administered when infants turned 3 months old and gross and fine motor development was assessed by the Ages and Stages Questionnaire (ASQ-3) at 6 months old. Infant gross motor scores were reverse coded so that higher scores indicated lower gross motor performance. Negative binomial regressions were performed to assess the relationship between household pesticide use and infant gross motor development.
RESULTS
Infants were predominantly Hispanic (78.7%) and full term (gestational age at birth: 39.0 ± 1.9 weeks), with 22.3% of maternal participants reporting household use of rodent and insect pesticides. Adjusting for recruitment site, maternal age, ethnicity, household income, education, infant corrected age, infant sex, and home type, infants with maternal-reported household use of rodent and insect pesticides had 1.30 times higher expected gross motor scores (95% confiidence interval 1.05, 1.61) than infants with no reported use of household pesticides, with higher scores indicating reduced gross motor performance.
CONCLUSIONS
Our results suggest household use of rodent and insect pesticides may harm infants' gross motor development in early childhood. Future research should evaluate the impact of specific household chemicals in infant biospecimens and their associations with infant motor development to confirm these findings.
背景
婴儿期运动技能的发展是至关重要的神经发育里程碑。尽管先前的研究已经探讨了农业农药对婴儿运动发育的神经毒性作用，但很少有研究调查早期产后家庭使用农药对婴儿运动发育的影响，特别是在城市社区。
目的
本研究旨在探讨早期产后家庭使用农药与 6 个月龄婴儿粗大运动和精细运动发育之间的关系。
方法
通过电话向 Maternal and Developmental Risks from Environmental and Social Stressors（MADRES）妊娠队列中的 296 对母婴进行问卷调查。在婴儿 3 个月大时通过问卷评估早期生活家庭农药使用情况，在 6 个月大时通过 Ages and Stages Questionnaire（ASQ-3）评估婴儿粗大运动和精细运动发育。婴儿粗大运动评分进行了反向编码，以便更高的分数表示更差的粗大运动表现。采用负二项回归评估家庭使用农药与婴儿粗大运动发育之间的关系。
结果
婴儿主要为西班牙裔（78.7%）和足月（出生时的胎龄：39.0±1.9 周），22.3%的产妇报告家庭使用了杀鼠剂和杀虫剂。调整招募地点、产妇年龄、种族、家庭收入、教育程度、婴儿矫正年龄、婴儿性别和家庭类型后，报告家庭使用杀鼠剂和杀虫剂的婴儿预期粗大运动评分高出 1.30 倍（95%置信区间 1.05，1.61），与未报告使用家庭农药的婴儿相比，得分越高表示粗大运动表现越差。
结论
我们的结果表明，家庭使用杀鼠剂和杀虫剂可能会损害婴儿在幼儿期的粗大运动发育。未来的研究应评估婴儿生物样本中特定家庭化学品的影响及其与婴儿运动发育的关联，以证实这些发现。
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