Department of Immunology, School of Medicine, Iran University of Medical Science, Tehran.
Department of Allergy, Rasool-e-Akram Hospital, Iran University of Medical Sciences, Tehran.
Monaldi Arch Chest Dis. 2021 Dec 28;92(3). doi: 10.4081/monaldi.2021.1697.
Asthma is a chronic and multifactorial disease which is known to result from environmental and genetic factors. Interleukin 1 receptor-like 1 (IL1RL1) is a receptor, which promotes inflammatory responses after binding to its ligand IL-33. Several studies have shown that IL1RL1 gene polymorphisms are related to susceptibility or protection to asthma. The objective of this study was to evaluate the association between two IL1RL1 single nucleotide polymorphisms (rs10208293 and rs1041973) and the risk of asthma in the Iranian population. We performed genotyping of the IL1RL1 SNPs in 126 adult asthmatics and 300 healthy controls using TaqMan genotyping assay. Moreover, total serum IgE level, eosinophil count, and skin prick test were accomplished. The results indicated that the AA genotype of rs10208293 was positively associated with asthma susceptibility (p=0.028). We did not find any association between rs1041973 and asthma. Overall, our findings indicate that rs10208293 has a positive association with asthma in the Iranian population.
哮喘是一种慢性多因素疾病，已知其由环境和遗传因素导致。白细胞介素 1 受体样 1（IL1RL1）是一种受体，在与配体 IL-33 结合后促进炎症反应。多项研究表明，IL1RL1 基因多态性与哮喘的易感性或保护有关。本研究旨在评估 IL1RL1 两个单核苷酸多态性（rs10208293 和 rs1041973）与伊朗人群哮喘风险之间的关联。我们使用 TaqMan 基因分型检测法对 126 例成年哮喘患者和 300 例健康对照者的 IL1RL1 SNPs 进行了基因分型。此外，还完成了总血清 IgE 水平、嗜酸性粒细胞计数和皮肤点刺试验。结果表明，rs10208293 的 AA 基因型与哮喘易感性呈正相关（p=0.028）。我们没有发现 rs1041973 与哮喘之间存在任何关联。总的来说，我们的研究结果表明，rs10208293 与伊朗人群的哮喘存在正相关。
