Department of Biochemistry and Biophysics, University of California San Francisco, Genentech Hall, 600 16th Street, San Francisco, California 94158, United States.
Chemistry and Chemical Biology Graduate Program, University of California San Francisco, Genentech Hall, 600 16th Street, San Francisco, California 94143, United States.
Biochemistry. 2022 Oct 18;61(20):2177-2181. doi: 10.1021/acs.biochem.1c00654. Epub 2021 Dec 29.
Plants obtain nutrients from the soil via transmembrane transporters and channels in their root hairs, from which ions radially transport in toward the xylem for distribution across the plant body. We determined structures of the hyperpolarization-activated channel AKT1 from , which mediates K uptake from the soil into plant roots. These structures of AtAKT1 embedded in lipid nanodiscs show that the channel undergoes a reduction of C4 to C2 symmetry, possibly to regulate its electrical activation.
植物通过根毛中的跨膜转运体和通道从土壤中获取养分，离子经根毛径向运输进入木质部，再在植物体内进行分配。我们解析了超极化激活通道 AKT1 的结构，AKT1 介导 K 从土壤中被吸收进入植物根部。这些嵌入在脂质纳米盘中的 AtAKT1 结构表明，该通道发生了 C4 到 C2 对称的减少，这可能调节了其电激活。
