Department of Dermatology and STDs, Dr RML Hospital and ABVIMS, New Delhi, India.
Department of Pathology, Dr. RML Hospital and ABVIMS, New Delhi, India.
J Cosmet Dermatol. 2022 Sep;21(9):4009-4015. doi: 10.1111/jocd.14709. Epub 2021 Dec 29.
Prurigo nodularis (PN) is a chronic dermatologic condition manifesting as multiple papulonodular lesions occurring on the background of intense pruritus. PN could be primary or secondary. The exact immune pathogenesis of PN is not yet clear, and multiple pathways are proposed with the JAK-STAT pathway rarely being investigated.
In this study, our aim was to assess the role of Th cells in PN by comparing the expression of STAT 1, 3, and 6 in involved and normal skin of primary prurigo nodularis.
A total of 49 clinico-histopathologically proven cases of primary prurigo nodularis were included. Two skin biopsies for each patient from lesional and non-lesional skin were stained with STAT 1, 3, and 6, and the nuclear staining pattern in the epidermis was graded as strong, moderate, weak, or none.
Statistically significant expression of STAT 3 and STAT 6 staining was seen in the epidermis of the lesional skin as compared to non-lesional skin.
Our study showed a marked dominance of STAT 3 and STAT 6 staining in the epidermis which signifies that the keratinocytes play an important role in PN and suggest that Th2, Th17, and Th22 cytokines mediate the tissue response in PN.
结节性痒疹（PN）是一种慢性皮肤病，表现为在剧烈瘙痒的背景下出现多个丘疹性结节病变。PN 可为原发性或继发性。PN 的确切免疫发病机制尚不清楚，提出了多种途径，很少研究 JAK-STAT 途径。
本研究旨在通过比较原发性结节性痒疹受累和正常皮肤中 STAT1、3 和 6 的表达，评估 Th 细胞在 PN 中的作用。
共纳入 49 例临床病理证实的原发性结节性痒疹病例。每位患者的皮损和非皮损皮肤均进行了 2 次皮肤活检，分别用 STAT1、3 和 6 染色，并对表皮的核染色模式进行强、中、弱或无分级。
与非皮损皮肤相比，皮损皮肤中 STAT3 和 STAT6 染色的表达具有统计学意义。
我们的研究表明，表皮中 STAT3 和 STAT6 染色明显占优势，这表明角质形成细胞在 PN 中起重要作用，并提示 Th2、Th17 和 Th22 细胞因子介导 PN 中的组织反应。
