Department of Anesthesiology, 12306Ohio State University, Columbus, OH, USA.
Semin Cardiothorac Vasc Anesth. 2022 Mar;26(1):83-85. doi: 10.1177/10892532211065234. Epub 2021 Dec 29.
Cefazolin is an antibiotic that is commonly administered perioperatively to reduce the risk of surgical site infections. Cephalosporins have a well-established safety profile, but have been associated with thrombocytopenia and neutropenia due to their myelosuppressive effects. While this effect may be benign in healthy patients undergoing minor surgery, it can be detrimental in patients with underlying hematologic disorders presenting for open-heart surgery. Herein, we discuss the first case in the literature of cefazolin-induced thrombocytopenia and severe coagulopathy in a patient with polycythemia vera (PCV) during a coronary artery bypass-grafting surgery.
头孢唑林是一种常用的围手术期抗生素，可降低手术部位感染的风险。头孢菌素具有良好的安全性，但由于其骨髓抑制作用，与血小板减少症和中性粒细胞减少症有关。虽然在接受小手术的健康患者中，这种作用可能是良性的，但在因开胸手术就诊的伴有潜在血液疾病的患者中，可能会产生不利影响。在此，我们讨论了文献中首例在接受冠状动脉旁路移植术的真性红细胞增多症（PCV）患者中，头孢唑林引起的血小板减少症和严重凝血功能障碍的病例。
