Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Centre for Translational Microbiome Research, Department of Microbiology Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Gut Microbes. 2022 Jan-Dec;14(1):2013761. doi: 10.1080/19490976.2021.2013761.
Fecal microbiota transplantation (FMT) is an efficient treatment for recurrent infection and currently investigated as a treatment for other intestinal and systemic diseases. Better understanding of the species potentially transferred in FMT is needed. We isolated from a healthy fecal donor a novel strain E10-96H of , a recently described strictly anaerobic species currently represented only by the type strain. The whole genome sequence of E10-96H had over 98% similarity with the type strain. E10-96H carries 20 glycoside hydrolase encoding genes, degrades starch and thus may contribute to fiber degradation, cross-feeding of other species and butyrate production in the intestinal ecosystem. The strain carries pilus-like structures, harbors pilin genes in its genome and adheres to enterocytes but does not provoke a proinflammatory response. seems to have commensal behavior with the host epithelium, and its role in intestinal ecology should be studied further.
粪便微生物群移植（FMT）是一种有效的复发性感染治疗方法，目前正在研究作为其他肠道和系统性疾病的治疗方法。需要更好地了解 FMT 中可能转移的物种。我们从一位健康的粪便供体中分离出一种新型的 菌株 E10-96H，这是一种最近描述的严格厌氧物种，目前仅由模式株代表。E10-96H 的全基因组序列与模式株相似度超过 98%。E10-96H 携带 20 个糖苷水解酶编码基因，可降解淀粉，因此可能有助于纤维降解、其他物种的交叉喂养和丁酸产生在肠道生态系统中。该菌株携带类似于菌毛的结构，其基因组中存在菌毛基因，并能黏附于肠上皮细胞，但不会引发炎症反应。 似乎与宿主上皮具有共生行为，其在肠道生态中的作用需要进一步研究。
