TIM-3 作为癌症患者有前途的诊断和预后生物标志物的展望。

Prospects of TIM-3 as a Promising Diagnostic and Prognostic Biomarker for Cancer Patients.

机构信息

National Center for International Research of Bio-targeting Theranostics, Guangxi Key Laboratory of Bio-targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Bio-targeting Theranostics, Guangxi Medical University, Nanning, Guangxi 530021, China.

Corresponding author.

出版信息

Discov Med. 2021 Jan-Feb;31(162):15-20.

PMID:34965367

Abstract

T cell immunoglobulin mucin-3 (TIM-3) is expressed on the surface of most immune cells and is involved in anti-tumor immunity. In recent years, diagnoses and therapies based on the TIM-3 target have advanced substantially in clinical trials. In this review, we summarized the progress of TIM-3 as a biomarker in the field of diagnosis and prognosis of cancer. In the peripheral blood of cancer patients, the expression level of TIM-3 on T cells is significantly higher than that of control samples, which can be a physiological indicator of cancer. Moreover, in the cancer tissue of patients, the high expression level of TIM-3 on tumor-infiltrating T cells is negatively correlated with relapse-free survival time, which can act as a promising prognostic marker. In conclusion, the TIM-3 is a promising biomarker for the diagnosis and prognosis of cancer.

摘要

T 细胞免疫球蛋白黏蛋白-3（TIM-3）表达于大多数免疫细胞表面，参与抗肿瘤免疫。近年来，基于 TIM-3 靶点的诊断和治疗在临床试验中取得了实质性进展。在这篇综述中，我们总结了 TIM-3 作为癌症诊断和预后标志物的研究进展。在癌症患者的外周血中，T 细胞上 TIM-3 的表达水平明显高于对照样本，这可以作为癌症的生理指标。此外，在患者的肿瘤组织中，肿瘤浸润性 T 细胞上 TIM-3 的高表达水平与无复发生存时间呈负相关，这可以作为一种有前途的预后标志物。总之，TIM-3 是癌症诊断和预后的一种很有前途的生物标志物。