Scott J R, Hendrickson M, Lash S, Shelby J
Obstet Gynecol. 1987 Aug;70(2):229-34.
A rat model was developed for microsurgical en bloc vascularized adnexal isografts and allografts. Transplantation of the fallopian tube and ovary from donors to syngeneic, bilaterally tubo-oophorectomized recipients was technically successful in six of eight animals, and four litters of healthy offspring were delivered at 44, 45, 85, and 105 days after transplantation. Twelve tubo-ovarian allografts using cyclosporine for immunosuppression resulted in seven viable grafts and three pregnancies. Cyclosporine at 15 mg/kg/day was found to be teratogenic, but normal progeny were delivered when the dose was lowered to 5 mg/kg/day during pregnancy. These results suggest that microsurgical tubal transplantation with an appropriate immunosuppressive regimen warrants further investigation as potential treatment for certain infertility problems in the human.
建立了一个用于显微外科整块带血管化附件同基因移植和异基因移植的大鼠模型。将供体的输卵管和卵巢移植到双侧输卵管卵巢切除的同基因受体中，8只动物中有6只在技术上获得成功，移植后44、45、85和105天产下了4窝健康后代。使用环孢素进行免疫抑制的12例输卵管卵巢异体移植中有7例移植物存活，3例怀孕。发现15毫克/千克/天的环孢素有致畸作用，但在怀孕期间将剂量降至5毫克/千克/天时可产下正常后代。这些结果表明，采用适当免疫抑制方案的显微外科输卵管移植作为人类某些不孕症问题的潜在治疗方法值得进一步研究。
