Department of Hematology and Infectious Disease, Gifu University Hospital, Gifu, Japan.
Department of Hematology, Matsunami General Hospital, Gifu, Japan.
Leuk Lymphoma. 2022 Jun;63(6):1323-1330. doi: 10.1080/10428194.2021.2020777. Epub 2021 Dec 29.
The controlling nutritional status (CONUT) score is a simplified nutritional index calculated from serum albumin, total cholesterol, and total lymphocyte count. This study evaluated the prognostic impact of the CONUT score on overall survival (OS) in patients with peripheral T-cell lymphoma (PTCL). A multicenter, retrospective cohort study including 99 patients with PTCL was conducted. The CONUT score was significantly higher in the non-survivor group (median 5, range 0-12) than in the survivor group (median 3, range 0-11; = 0.026). The CONUT score was an independent prognostic factor in a multivariable Cox proportional hazards model (hazard ratio 1.119, 95% confidence interval 1.021-1.227, = 0.017). No significant effect-modification by the International Prognostic Index (IPI) was observed, and the CONUT score affected the prognosis of PTCL regardless of the IPI ( for interaction = 0.208). In conclusion, the CONUT score is an independent prognostic factor for PTCL irrespective of IPI category.
控制营养状态（CONUT）评分是一种从血清白蛋白、总胆固醇和总淋巴细胞计数计算得出的简化营养指数。本研究评估了 CONUT 评分对周围 T 细胞淋巴瘤（PTCL）患者总生存期（OS）的预后影响。进行了一项多中心、回顾性队列研究，纳入了 99 例 PTCL 患者。非生存组的 CONUT 评分显著高于生存组（中位数 5，范围 0-12）（=0.026）。CONUT 评分在多变量 Cox 比例风险模型中是一个独立的预后因素（风险比 1.119，95%置信区间 1.021-1.227，=0.017）。国际预后指数（IPI）未观察到明显的效应修饰作用，CONUT 评分影响 PTCL 的预后，与 IPI 无关（交互作用=0.208）。总之，CONUT 评分是 PTCL 的一个独立预后因素，与 IPI 类别无关。
