Al-Zubi Mohammad, Araydah Mohammad, Al Sharie Sarah, Qudsieh Suhair Adel, Abuorouq Saleh, Qasim Tariq Shawqi
Department of Clinical Sciences, Urology Division, Faculty of Medicine, Yarmouk University, Irbid, Jordan.
Faculty of Medicine, Yarmouk University, Irbid, Jordan.
Int J Surg Case Rep. 2022 Jan;90:106733. doi: 10.1016/j.ijscr.2021.106733. Epub 2021 Dec 27.
Leydig cell hyperplasia or tumor represents less than 3% of all testicular tumors. It can be defined as an increase in the size and number of Leydig cell within the testicles. These cells are responsible for the production of testosterone in human males.
Our patient is a forty-eight-year-old male presented with erectile dysfunction and decreased libido for the past six months. Ultrasound of the scrotum show bilateral hypoechoic testicular masses larger on the left size thus left orchidectomy was performed. Histopathology confirmed our diagnosis.
Leydig cell hyperplasia (LCH) is a rare and mostly benign entity that affects both children and adults. In adults, it might be associated with variety of condition including Klinefelter's syndrome, exogenous human chorionic gonadotropin (hCG) therapy, and many others but it mostly occurs idiopathically. Scrotal ultrasound and tumor markers can be used to diagnose most of the patients with LCH.
LCH should be differentiated from Leydig cell tumor to avoid unnecessary and sometimes harmful intervention in the future.
睾丸间质细胞增生或肿瘤占所有睾丸肿瘤的比例不到3%。它可被定义为睾丸内间质细胞的大小和数量增加。这些细胞负责男性体内睾酮的产生。
我们的患者是一名48岁男性，在过去六个月中出现勃起功能障碍和性欲减退。阴囊超声显示双侧睾丸低回声肿块，左侧更大，因此进行了左侧睾丸切除术。组织病理学证实了我们的诊断。
睾丸间质细胞增生（LCH）是一种罕见的、大多为良性的病症，可影响儿童和成人。在成年人中，它可能与多种病症有关，包括克兰费尔特综合征、外源性人绒毛膜促性腺激素（hCG）治疗等，但大多为特发性发生。阴囊超声和肿瘤标志物可用于诊断大多数LCH患者。
应将LCH与睾丸间质细胞瘤区分开来，以避免未来进行不必要的、有时甚至是有害的干预。
