Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, U.S.A.;
Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ, U.S.A.
Anticancer Res. 2022 Jan;42(1):53-57. doi: 10.21873/anticanres.15456.
BACKGROUND/AIM: To evaluate the change in lumpectomy cavity (LPC) volume during hypofractionated radiation (Hypo-RT) and assess the dosimetric benefits of adaptive boost planning on normal tissue exposure in breast cancer patients.
Two separate computed tomography (CT) simulation scans were obtained. The first (CT1) was used to plan whole breast irradiation, and the second (CT2) was used to plan LPC boost. LPC boost treatment planning was performed on both CT1 and CT2.
Mean LPC volume was significantly smaller on CT2 compared to CT1. LPC boost plan comparison showed significant reductions from CT1 to CT2 in mean heart dose and mean lung dose. Mean volume of tissue receiving 95% of the prescribed boost dose (V95) was lower on CT2 (p=0.001), as was V80 (p<0.001) and V50 (p<0.001).
LPC volume can change significantly during Hypo-RT. Adaptive LPC boost planning can be considered to reduce normal tissue exposure.
背景/目的：评估乳腺癌患者在接受 Hypo-RT 期间的肿瘤切腔（LPC）体积变化，并评估自适应 boost 计划对正常组织照射的剂量学优势。
获得两次独立的计算机断层扫描（CT）模拟扫描。第一次（CT1）用于计划全乳照射，第二次（CT2）用于计划 LPC 加量。在 CT1 和 CT2 上进行 LPC 加量治疗计划。
与 CT1 相比，CT2 上的 LPC 体积明显更小。LPC 加量计划的比较显示，与 CT1 相比，CT2 上的平均心脏剂量和平均肺剂量均显著降低。处方加量剂量的 95%（V95）所覆盖的组织平均体积在 CT2 上较低（p=0.001），V80（p<0.001）和 V50（p<0.001）也较低。
LPC 体积在 Hypo-RT 期间可能会发生显著变化。可以考虑自适应 LPC 加量计划来减少正常组织照射。
