Department of Gynecology. Division Gynecologic Oncology, Cleveland Clinic Florida, Weston, FL, U.S.A.
Division of Quantitative Science and Biostatistics Shared Resource, University of Florida Health Cancer Center, Gainesville, FL, U.S.A.
Anticancer Res. 2022 Jan;42(1):75-85. doi: 10.21873/anticanres.15459.
BACKGROUND/AIM: To analyze the impact of minimally invasive surgery for endometrial cancer on overall survival among age >65.
We examined women who underwent hysterectomy from 2010 to 2015 from the U.S. National Cancer Data Base (NCDB). We evaluated the impact of surgical approach on survival.
Of 243,601 endometrial cancer cases, 42,458 met the inclusion criteria. Laparoscopic approach was associated with improved survival by 14% (HR=0.86; 95%CI=0.80-0.92; p<0.001) and robotic approach was associated with improved survival by 12% (HR=0.88; 95%CI=0.83-0.93; p<0.0001), compared to the open approach. Similarly, the weighted adjusted 5-year overall survival was 73.1% (95%CI=72%-74.2%), 76.4% (95%CI=75.1-77.7%), and 75.5% (95%CI=74.7-76.4%) for open, laparoscopic, and robotic approaches, respectively (p<0.001).
Minimally invasive surgery improved overall survival in women over 65 years with endometrial cancer.
背景/目的：分析子宫内膜癌微创手术对 65 岁以上患者总生存率的影响。
我们研究了 2010 年至 2015 年期间美国国家癌症数据库（NCDB）中接受子宫切除术的女性。我们评估了手术方式对生存的影响。
在 243601 例子宫内膜癌病例中，42458 例符合纳入标准。与开放手术相比，腹腔镜手术使生存率提高了 14%（HR=0.86；95%CI=0.80-0.92；p<0.001），机器人手术使生存率提高了 12%（HR=0.88；95%CI=0.83-0.93；p<0.0001）。同样，加权调整后的 5 年总生存率分别为开放、腹腔镜和机器人手术组的 73.1%（95%CI=72%-74.2%）、76.4%（95%CI=75.1-77.7%）和 75.5%（95%CI=74.7-76.4%）（p<0.001）。
对于 65 岁以上患有子宫内膜癌的女性，微创手术可提高总体生存率。
