放射性金粒近距离治疗复发性口腔癌病例：既往行根治性放疗。
Reirradiation Using Au Grain Brachytherapy for Recurrent Oral Cancer Cases Previously Treated by Definitive Radiotherapy.
机构信息
Department of Oral and Maxillofacial Radiology, Hiroshima University Hospital, Hiroshima, Japan
Department of Radiation Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
出版信息
Anticancer Res. 2022 Jan;42(1):293-300. doi: 10.21873/anticanres.15485.
BACKGROUND/AIM: We investigated treatment outcomes and complications during reirradiation of patients with oral cancers.
PATIENTS AND METHODS
Six patients who received definitive radiotherapy for oral cancer as the initial treatment and brachytherapy for recurrence were included. Local control and overall survival rates, soft tissue and mandibular complications, and tooth extraction were investigated.
RESULTS
The five-year local control and overall survival rates were 83.3% and 100%, respectively. The occurrence rate of grade 2 soft tissue and mandible complications was 33.3%, and the primary sites were the buccal mucosa and the floor of mouth. The positions of the extracted tooth in the two cases were adjacent to the tumor, and one case developed grade 2 complication of the mandible.
CONCLUSION
During recurrence of the buccal mucosa and the floor of mouth cancers, reirradiation should be avoided considering mandibular complications. To avoid reirradiation-related complications, tooth extraction near the radiation field should be avoided.
背景/目的：我们研究了口腔癌患者再放疗的治疗效果和并发症。
患者和方法
纳入了 6 名患者，他们最初接受了根治性放疗治疗口腔癌，后来复发时接受了近距离放疗。我们调查了局部控制率和总生存率、软组织和下颌并发症以及拔牙情况。
结果
5 年局部控制率和总生存率分别为 83.3%和 100%。2 级软组织和下颌并发症的发生率为 33.3%，原发部位为颊黏膜和口底。2 例拔牙部位紧邻肿瘤，1 例下颌出现 2 级并发症。
结论
对于颊黏膜和口底癌的复发，考虑到下颌并发症，应避免再放疗。为了避免与放疗相关的并发症，应避免在放射野附近拔牙。
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