吸烟对导管癌进展为浸润性导管乳腺癌的影响：一项回顾性研究。
The Effect of Smoking on Progression from Ductal Carcinoma to Invasive Ductal Breast Carcinoma: A Retrospective Study.
机构信息
Department of Breast and Endocrine Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
Department of Breast and Endocrine Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan
出版信息
Anticancer Res. 2022 Jan;42(1):311-320. doi: 10.21873/anticanres.15487.
BACKGROUND/AIM: If ductal carcinoma in situ (DCIS) is diagnosed by needle biopsy, invasion is often found by removing the entire tumor and performing pathological examination. Smoking is a risk factor for carcinogenesis in breast cancer. We examined the correlation between the risk of invasion found by postoperative pathology and smoking history in patients diagnosed with DCIS by preoperative biopsy.
PATIENTS AND METHODS
We examined 128 patients who were diagnosed with DCIS by preoperative biopsy. Multivariate analysis was performed on the risk factors for invasion diagnosed by postoperative pathological examination in all cases diagnosed with DCIS by preoperative biopsy.
RESULTS
Multivariate analysis was performed on the risk factors for invasion diagnosed by postoperative pathological examination in all cases diagnosed with DCIS by preoperative biopsy. Number of pack-years was not an independent factor (p=0.349, OR=0.329), but current-smoker status (p=0.006, OR=not calculable) was an independent factor with VAB (p=0.018, OR=0.327).
CONCLUSION
Tobacco components may have an influence on the progression from DCIS to invasive ductal carcinoma.
背景/目的：如果通过针吸活检诊断为导管原位癌（DCIS），通常会通过切除整个肿瘤并进行病理检查来发现浸润。吸烟是乳腺癌发生癌变的一个危险因素。我们研究了术前活检诊断为 DCIS 的患者中，术后病理发现浸润的风险与吸烟史之间的相关性。
患者和方法
我们检查了 128 例经术前活检诊断为 DCIS 的患者。对所有经术前活检诊断为 DCIS 的病例，进行了术后病理检查发现浸润的危险因素的多因素分析。
结果
对所有经术前活检诊断为 DCIS 的病例，进行了术后病理检查发现浸润的危险因素的多因素分析。吸烟包年数不是独立的危险因素（p=0.349，OR=0.329），但目前吸烟状态（p=0.006，OR=无法计算）是 VAB 的独立危险因素（p=0.018，OR=0.327）。
结论
烟草成分可能对 DCIS 向浸润性导管癌的进展有影响。
Zotero 插件