Copine 1 在肾细胞癌患者中的预后价值。

Prognostic Value of Copine 1 in Patients With Renal Cell Carcinoma.

机构信息

College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.

Pathology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

出版信息

Anticancer Res. 2022 Jan;42(1):355-362. doi: 10.21873/anticanres.15493.

DOI:10.21873/anticanres.15493

PMID:34969745

Abstract

BACKGROUND/AIM: Renal cell carcinoma (RCC) is among the most common renal malignancies and requires reliable biomarkers for optimum diagnosis and prognosis. Copines are a family of calcium-dependent phospholipid-binding proteins that were reported to be associated with various cancers. We aimed to investigate the prognostic value of Copines 1 and 3 in RCC patients.

MATERIALS AND METHODS

Copines 1 and 3 bioinformatics analysis and immunohistochemical (IHC) staining were performed on patients with RCC.

RESULTS

The findings revealed significant association between Copine 1 expression and the patients' age, nuclear grade, and tumor stage. Bioinformatics analysis showed a similar trend for the mRNA expression of CPNE1, the gene that encodes Copine 1. Interestingly, results revealed a positive association between Copine 1 and both EphA and Ki-67 expression levels. Noteworthy, there was no significant association between Copine 3 expression and any parameters.

CONCLUSION

Copine 1 may be used as an independent biomarker or in combination with both EphA2 and Ki-67 to predict disease outcome.

摘要

背景/目的：肾细胞癌（RCC）是最常见的肾恶性肿瘤之一，需要可靠的生物标志物来进行最佳诊断和预后。Copines 是一组依赖于钙的磷脂结合蛋白家族，据报道与各种癌症有关。我们旨在研究 Copines 1 和 3 在 RCC 患者中的预后价值。

材料和方法

对 RCC 患者进行 Copines 1 和 3 的生物信息学分析和免疫组织化学（IHC）染色。

结果

研究结果表明 Copine 1 表达与患者年龄、核分级和肿瘤分期之间存在显著相关性。基因 CPNE1 编码 Copine 1，其 mRNA 表达的生物信息学分析也显示出类似的趋势。有趣的是，结果显示 Copine 1 与 EphA 和 Ki-67 的表达水平呈正相关。值得注意的是，Copine 3 表达与任何参数之间均无显著相关性。