Kaur Rajandeep, Chauhan Anshika, Bhat Shabir Ahmad, Chatterjee Debajyoti, Ghoshal Sushmita, Pal Arnab
Biochemistry, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
J Clin Pathol. 2022 May;75(5):289-291. doi: 10.1136/jclinpath-2021-208011. Epub 2021 Dec 30.
Cornulin () gene encodes a 495 amino acid long protein and is located on chromosome 1q21.3. Primarily, it functions as the marker of differentiation. Initially, it was found to be specific for the squamous cells of oesophagus. However, later on, several studies have revealed the presence of Cornulin downregulation in various epithelial squamous cell carcinomas of the head and neck, oesophagus and cervix and clinically associated it with worsening of cancer and the poor prognosis. Cornulin levels also showed dysregulation in other diseases such as Eczema and Psoriasis. Besides the differentiation marker, it was identified to be involved in the stress response. The studies, in psoriasis and oesophageal squamous cell carcinoma, has elucidated that the dysregulation in the Cornulin is associated with the cell cycle events such as G1/S transition. However, the actual function of Cornulin is still yet to be explored in detail.
角质素（）基因编码一种由495个氨基酸组成的蛋白质，位于1号染色体的1q21.3位置。它主要作为分化标志物发挥作用。最初，它被发现对食管鳞状细胞具有特异性。然而，后来的多项研究表明，在头颈部、食管和宫颈的各种上皮鳞状细胞癌中存在角质素下调的情况，并且在临床上发现其与癌症恶化及预后不良相关。角质素水平在湿疹和银屑病等其他疾病中也显示出失调。除了作为分化标志物外，它还被确定参与应激反应。在银屑病和食管鳞状细胞癌中的研究表明，角质素的失调与细胞周期事件如G1/S转换有关。然而，角质素的实际功能仍有待详细探索。
