Togashi T, Kuwajima S, Ozutsumi K, Chubachi T, Shibata M, Matsumoto S
Hokkaido Igaku Zasshi. 1987 Mar;62(2):250-6.
Thirty five children with tuberculosis admitted to the Hokkaido University Hospital from 1970 through 1984 wer reviewed. They were 7 cases of meningeal tuberculosis, 8 of military tuberculosis, 15 of primary tuberculosis and 5 of adult type pulmonary tuberculosis. Fifteen (43%) of the 35 cases were below 2 years, and over half of these younger cases were hematogenous spread such as meningeal and military types. Instead of hematogenic spread in these cases, erythrocyte sedimentation rate and CRP stayed in moderate values. Thirty one (91.2%) of the 34 cases having precise record had no history of BCG inoculation. Over half of the cases were infected from adults in the immediate household, and the sources of infection were found after the diagnosis of childhood tuberculosis in about half of these cases. Although incidence of the childhood tuberculosis are decreasing in recent years, childhood tuberculosis resulting hematogenous spread with poor prognosis in advanced state still exists, so it is important to remark the childhood tuberculosis at out patient clinics.
对1970年至1984年间入住北海道大学医院的35例结核病患儿进行了回顾性研究。其中结核性脑膜炎7例,粟粒性结核病8例,原发性结核病15例,成人型肺结核5例。35例中15例(43%)年龄在2岁以下,这些年龄较小的病例中超过半数为血行播散型,如结核性脑膜炎和粟粒性结核。在这些病例中,尽管不是血行播散型,但红细胞沉降率和CRP仍处于中等水平。34例有确切记录的病例中,31例(91.2%)无卡介苗接种史。超过半数的病例是由直系亲属中的成人感染所致,约半数病例在儿童结核病诊断后才发现感染源。尽管近年来儿童结核病的发病率在下降,但处于晚期且预后较差的血行播散型儿童结核病仍然存在,因此在门诊重视儿童结核病很重要。