CD38 是否参与 T 细胞受体激活引起的钙信号转导？
Is CD38 involved in Ca signalling elicited by activation of T cell receptors?
机构信息
School of Biosciences, Cardiff University, Cardiff CF10 3AT, Wales, United Kingdom.
出版信息
Cell Calcium. 2022 Jan;101:102524. doi: 10.1016/j.ceca.2021.102524. Epub 2021 Dec 27.
PMID:34971841
Abstract
A recent publication proposes that T cell receptor activation elicits formation of the Ca releasing messenger NAADP from NAADPH, catalysed by the NADPH oxidase DUOX. This is in contrast to the hitherto prevailing view that CD38 is critical for NAADP formation. Is it time to reassess the role of CD38?
摘要
最近的一篇出版物提出，T 细胞受体的激活会引发 NADPH 产生钙释放信使 NAADP，这一过程由 NADPH 氧化酶 DUOX 催化。这与迄今占主导地位的观点形成了对比，即 CD38 对于 NAADP 的形成至关重要。现在是否需要重新评估 CD38 的作用？
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