Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Internal Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Am J Otolaryngol. 2022 Mar-Apr;43(2):103329. doi: 10.1016/j.amjoto.2021.103329. Epub 2021 Dec 15.
The submandibular gland is commonly removed during neck dissection in patients with head and neck cancer. The patient experiences various complications due to the removal of the submandibular gland. Therefore, the necessity of submandibular gland removal should be evaluated. This study aimed to was to determine the frequency of submandibular gland (SMG) involvement in patients with oral cavity squamous cell carcinoma (SCC).
In this retrospective study, medical records of patients with oral cavity cancer who were referred to Amir Alam Hospital between 2015 and 2020 were reviewed. Patient data includes surgical report, histopathology report (tumor size, number of lymph nodes involved, and SMG tumor involvement), Tumor Location, History of Smoking, History of Opium, and Alcohol consumption was extracted from patients' medical records and statistically analyzed using SPSS software version 20.
Of the total 60 patients, 24 (40%) were female and 36 (60%) were male. Smoking was reported in 55% of patients with a mean of 4.11 pack-year. Alcohol and opium use was observed in 18.3% and 26% of patients. The majority of patients (78.3%) had tongue cancer. More than half of the patients (53.3%) reported tumors of 2 cm or smaller, and 16.7% of patients had tumors larger than 4 cm. The majority of patients (80.3%) did not have cervical lymph node metastasis, 13.1% had 1-2 involved lymph nodes and 4.9% had 3 to 6 involved lymph nodes and there were no cases of metastasis to more than 6 lymph nodes. Finally, no individual had submandibular gland involvement, ie 100% of patients had no submandibular gland metastasis.
The results confirmed that SMG involvement is very rare in patients with oral SCC and therefore it is not necessary to remove the gland as part of treatment. Preservation of the submandibular gland prevents complications related to the removal of this gland and reduces morbidity and increases the quality of life of patients after surgery.
在头颈部癌症患者的颈部清扫术中，通常会切除下颌下腺。由于下颌下腺的切除，患者会经历各种并发症。因此，有必要评估切除下颌下腺的必要性。本研究旨在确定口腔鳞状细胞癌（SCC）患者下颌下腺（SMG）受累的频率。
在这项回顾性研究中，回顾了 2015 年至 2020 年间转诊至 Amir Alam 医院的口腔癌患者的病历。患者数据包括手术报告、组织病理学报告（肿瘤大小、受累淋巴结数量和 SMG 肿瘤受累情况）、肿瘤位置、吸烟史、阿片类药物史和酒精摄入情况，从患者病历中提取并使用 SPSS 软件版本 20 进行统计分析。
在 60 名患者中，24 名（40%）为女性，36 名（60%）为男性。55%的患者报告有吸烟史，平均吸烟量为 4.11 包年。18.3%和 26%的患者有酒精和鸦片使用史。大多数患者（78.3%）患有舌癌。超过一半的患者（53.3%）报告肿瘤为 2cm 或更小，16.7%的患者肿瘤大于 4cm。大多数患者（80.3%）无颈部淋巴结转移，13.1%有 1-2 个受累淋巴结，4.9%有 3-6 个受累淋巴结，无转移至 6 个以上淋巴结的病例。最后，没有个体出现下颌下腺受累，即 100%的患者没有下颌下腺转移。
结果证实，口腔 SCC 患者下颌下腺受累非常罕见，因此，作为治疗的一部分，无需切除该腺体。保留下颌下腺可预防与切除该腺体相关的并发症，降低发病率，提高患者术后生活质量。
