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中低收入国家面临的抗菌药物耐药性威胁:当前的监测实践和控制措施以应对挑战。

Menace of antimicrobial resistance in LMICs: Current surveillance practices and control measures to tackle hostility.

机构信息

Department of Pharmacy Practice, National Institute of Pharmaceutical Education and Research (NIPER), Hajipur, Bihar, India.

Department of Pharmacology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

出版信息

J Infect Public Health. 2022 Feb;15(2):172-181. doi: 10.1016/j.jiph.2021.12.008. Epub 2021 Dec 17.

Abstract

Antimicrobial Resistance (AMR) is significant challenge humanity faces today, with many patients losing their lives every year due to AMR. It is more widespread and has shown a higher prevalence in low- and middle-income countries (LMICs) due to lack of awareness and other associated reasons. WHO has suggested some crucial guidelines and specific strategies such as antimicrobial stewardship programs taken at the institutional level to combat AMR. Creating awareness at the grassroots level can help to reduce the AMR and promote safe and effective use of antimicrobials. Control strategies in curbing AMR also comprise hygiene and sanitation as microbes travel from contaminated surroundings to the human body surface. As resistance to multiple drugs increases, vaccines can play a significant role in curbing the menace of AMR. This article summarizes the current surveillance practices and applied control measures to tackle the hostility in these countries with particular reference to the role of antimicrobial stewardship programs and the responsibilities of regulatory authorities in managing the situation.

摘要

抗微生物药物耐药性(AMR)是当今人类面临的重大挑战,每年有许多患者因 AMR 而失去生命。由于缺乏认识和其他相关原因,中低收入国家(LMICs)的 AMR 更为普遍,发病率更高。世卫组织提出了一些关键的准则和具体策略,例如在机构层面采取抗菌药物管理计划来对抗 AMR。在基层提高认识有助于减少 AMR 和促进安全有效的使用抗菌药物。控制 AMR 的策略还包括卫生和环境卫生,因为微生物从受污染的环境传播到人体表面。随着对多种药物的耐药性增加,疫苗在遏制 AMR 的威胁方面可以发挥重要作用。本文总结了目前针对这些国家的监测做法和应用的控制措施,特别提到了抗菌药物管理计划的作用以及监管机构在管理这一局面方面的责任。

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