氨基酸可能对 5-FU 处理的小鼠唾液腺具有保护作用。
Amino Acids May Have Protective Effects on Salivary Glands of 5-FU-administered Mice.
机构信息
Department of Oral and Maxillofacial Surgery, Yamaguchi University Graduate School of Medicine, Ube, Japan.
Department of Oral and Maxillofacial Surgery, Yamaguchi University Graduate School of Medicine, Ube, Japan
出版信息
In Vivo. 2022 Jan-Feb;36(1):198-205. doi: 10.21873/invivo.12691.
BACKGROUND/AIM: This study aimed to identify the most useful components of Elental in the treatment of 5-fluorouracil (FU)-induced mucositis and salivary gland atrophy in mice.
MATERIALS AND METHODS
Mice (except the control group) were intraperitoneally injected with 5-FU. The mice received saline (control group and 5-FU group), dextrin (Dextrin group), amino acids (17AA group), or Elental (Elental group).
RESULTS
The volume and weight of salivary glands was higher in 17AA and Elental groups compared to 5-FU group. The number of mucous glands was higher, whereas the number of damaged granular ductal epithelial cells was lower in the salivary glands of all groups except the 5-FU group. Salivation was also decreased in the 5-FU group compared to the other groups.
CONCLUSION
Amino acids could be the most effective components of Elental for protecting mouse salivary glands from 5-FU-induced atrophic changes, and might be useful in the treatment of oral mucositis in cancer patients.
背景/目的：本研究旨在确定艾替班特治疗氟尿嘧啶（5-FU）诱导的小鼠粘膜炎和唾液腺萎缩中最有用的成分。
材料和方法
给小鼠（对照组除外）腹腔注射 5-FU。小鼠接受生理盐水（对照组和 5-FU 组）、糊精（糊精组）、氨基酸（17AA 组）或艾替班特（艾替班特组）。
结果
与 5-FU 组相比，17AA 和艾替班特组的唾液腺体积和重量更高。除 5-FU 组外，各组的粘液腺数量增加，而颗粒状导管上皮细胞损伤数量减少。与其他组相比，5-FU 组的唾液分泌量也减少。
结论
氨基酸可能是艾替班特保护小鼠唾液腺免受 5-FU 诱导的萎缩性改变的最有效成分，可能对癌症患者口腔粘膜炎的治疗有用。
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