在一个综合面板中联合使用 GATA3、SOX-10 和 PAX8 来诊断乳腺癌转移。
Combination of GATA3, SOX-10, and PAX8 in a Comprehensive Panel to Diagnose Breast Cancer Metastases.
机构信息
Department of Pathology, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Republic of Korea.
Department of Pathology, National Cancer Center, Goyang, Republic of Korea.
出版信息
In Vivo. 2022 Jan-Feb;36(1):473-481. doi: 10.21873/invivo.12727.
BACKGROUND/AIM: It can be difficult to establish the origin of a tumor in metastatic breast cancer (MBC), especially with triple-negative breast cancer (TNBC) or high-grade features. We evaluated the diagnostic utility of GATA3, SOX10, and PAX8 panels in MBC by comparing their expression in each molecular subtype of MBC.
PATIENTS AND METHODS
We evaluated 84 MBC and 37 primary TNBC cases using GATA3, SOX10, and PAX8 staining in whole tissue sections.
RESULTS
GATA3 was least sensitive in the detection of metastatic TNBC (metastatic non-TNBC, 0.95; metastatic TNBC, 0.37). SOX10 had the lowest overall sensitivity (0.12) but was elevated in metastatic TNBC, even higher than GATA3 (0.59 vs. 0.37). The combination of GATA3, SOX10, and PAX8 expression showed the highest detection rate (MBC, 0.94; metastatic non-TNBC, 0.95; metastatic TNBC, 0.93).
CONCLUSION
We recommend combining GATA3, SOX10, PAX8 expression profiling to confirm breast as the site of origin in metastatic MBC.
背景/目的：转移性乳腺癌（MBC），尤其是三阴性乳腺癌（TNBC）或高级别特征，其肿瘤起源可能难以确定。我们通过比较 GATA3、SOX10 和 PAX8 表达谱在 MBC 各分子亚型中的表达，评估了 GATA3、SOX10 和 PAX8 联合检测在 MBC 中的诊断效用。
患者和方法
我们在全组织切片中使用 GATA3、SOX10 和 PAX8 染色评估了 84 例 MBC 和 37 例原发性 TNBC 病例。
结果
GATA3 在转移性 TNBC 检测中的敏感性最低（转移性非 TNBC，0.95；转移性 TNBC，0.37）。SOX10 的总体敏感性最低（0.12），但在转移性 TNBC 中升高，甚至高于 GATA3（0.59 比 0.37）。GATA3、SOX10 和 PAX8 联合表达的检测率最高（MBC，0.94；转移性非 TNBC，0.95；转移性 TNBC，0.93）。
结论
我们建议联合 GATA3、SOX10、PAX8 表达谱分析，以确认转移性 MBC 中乳腺为起源部位。
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