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城市三级保健医疗中心子痫前期患者严重产时高血压的流行状况和处理。

Prevalence and management of severe intrapartum hypertension in patients with preeclampsia at an urban tertiary care medical center.

机构信息

University of Chicago Pritzker School of Medicine, Chicago, IL, USA.

Department of Obstetrics and Gynecology, Division of Maternal Fetal Medcine, The University of Chicago, Chicago, IL, USA.

出版信息

Pregnancy Hypertens. 2022 Mar;27:87-93. doi: 10.1016/j.preghy.2021.12.011. Epub 2021 Dec 25.

Abstract

OBJECTIVES

Data on management of severe intrapartum hypertension is lacking. The aim of this study is to explore the proportion of timely interventions in severe, persistent intrapartum hypertension treatment by exploring the prevalence and management of intrapartum hypertension trends.

STUDY DESIGN

This was a retrospective case-control study of pregnant women who delivered at the University of Chicago between January 2015 and March 2017. Patients with severe preeclampsia who underwent labor (either induced or spontaneous) were stratified into two groups: severe intrapartum hypertension and no severe intrapartum hypertension.

MAIN OUTCOME MEASURES

Type of treatment and timing to treatment of severe hypertensive episodes were explored as well as prevalence of maternal adverse outcomes.

RESULTS

A total of 95 patients with severe preeclampsia in labor were identified. In patients with persistent severe intrapartum hypertension (n = 52), 15 (28.9%) received treatment. Patients experiencing greater than three episodes of blood pressure elevation were more likely to receive treatment as compared to those with fewer episodes. There was no significant difference in severe maternal morbidity (SMM) between those treated within 60 min compared to those untreated or treated after 60 min (16.7% vs 27.5%; p = 0.71).

CONCLUSIONS

Management protocols of intrapartum hypertensive episodes are variable or not universally implemented. Inadequately treated episodes of severe intrapartum hypertension trend towards higher rates of SMM.

摘要

目的

关于严重产时高血压管理的数据尚缺乏。本研究旨在通过探讨产时高血压趋势的流行情况和管理方式,来探究及时干预严重持续性产时高血压治疗的比例。

研究设计

这是一项回顾性病例对照研究,纳入了 2015 年 1 月至 2017 年 3 月期间在芝加哥大学分娩的孕妇。将患有严重先兆子痫并接受分娩(无论是引产还是自然分娩)的患者分为两组:严重产时高血压组和无严重产时高血压组。

主要观察指标

探讨严重高血压发作的治疗类型和治疗时机,并探讨产妇不良结局的发生率。

结果

共确定了 95 例患有严重先兆子痫的临产患者。在持续性严重产时高血压患者(n=52)中,有 15 例(28.9%)接受了治疗。与发作次数较少的患者相比,发作次数超过三次的患者更有可能接受治疗。与未在 60 分钟内治疗或治疗时间超过 60 分钟的患者相比,在 60 分钟内接受治疗的患者发生严重产妇发病率(SMM)的差异无统计学意义(16.7%比 27.5%;p=0.71)。

结论

产时高血压发作的管理方案存在差异或未普遍实施。治疗不充分的严重产时高血压发作倾向于导致更高的 SMM 发生率。

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本文引用的文献

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Preeclampsia: Pathophysiology, Challenges, and Perspectives.子痫前期:病理生理学、挑战与展望。
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Contribution of hypertension to severe maternal morbidity.高血压对严重孕产妇发病率的影响。
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