Department of Pathology, Beijing Haidian Maternal and Child Health Hospital, Beijing 100080, China.
Prenatal Diagnosis Center, Beijing Haidian Maternal and Child Health Hospital, Beijing 100080, China.
Ann Diagn Pathol. 2022 Apr;57:151873. doi: 10.1016/j.anndiagpath.2021.151873. Epub 2021 Dec 7.
To explore clinicopathological characteristics, diagnosis, differential diagnoses, treatment, and prognoses of placental chorioangioma (PCA).
Placenta of 77 cases of PCA firmly diagnosed by pathology from 2009 through 2019 were collected, and clinicopathological characteristics of the patients were retrospectively analyzed.
Seventy-seven patients were 20-41 (mean age, 28.8) years old at onset. Thirty patients showed pregnancy comorbidity. In one patient with the largest tumor (diameter, 16 cm), intrauterine fetal demise occurred at 33 weeks of gestation. Tumors were macroscopically manifested. The placental fetal surface showed a raised dark red to a pale pink nodule, quasi-round, with a maximum diameter of 0.2-16 cm. Microscopically, the tumors had a lot of capillaries and some interstitial loose connective tissue. One case was of atypical cellular chorioangioma. Immunophenotypically, CD34 (+) and Ki-67 proliferation indexes were less than 10%.
Large PCA often accompanies pregnancy comorbidity. Atypical cellular chorangioma is rare and may be misdiagnosed as a malignant tumor. Therefore, improvement of understanding of such tumors can provide a basis for clinical diagnosis and intervention.
探讨胎盘绒毛血管瘤（PCA）的临床病理特征、诊断、鉴别诊断、治疗和预后。
收集 2009 年至 2019 年病理确诊的 77 例胎盘绒毛血管瘤患者的胎盘，回顾性分析患者的临床病理特征。
77 例患者发病年龄为 20-41 岁（平均年龄 28.8 岁）。30 例患者伴有妊娠合并症。在 1 例最大肿瘤（直径 16cm）患者中，胎儿于 33 周时宫内死亡。肿瘤在肉眼下表现为明显的凸起的暗红色至淡粉色结节，类圆形，最大直径 0.2-16cm。显微镜下，肿瘤有大量毛细血管和一些间质疏松结缔组织。1 例为非典型细胞绒毛血管瘤。免疫表型上，CD34（+）和 Ki-67 增殖指数均小于 10%。
大的 PCA 常伴有妊娠合并症。非典型细胞绒毛血管瘤罕见，可能误诊为恶性肿瘤。因此，提高对这类肿瘤的认识可为临床诊断和干预提供依据。
