Department of Medicine, The Aga Khan University, Karachi, Pakistan.
Department of Health Sciences, The University of York, York, United Kingdom.
J Pak Med Assoc. 2021 Oct;71(10):2330-2334. doi: 10.47391/JPMA.01-107.
To compare the characteristics of connective tissue disease-associated interstitial lung disease with idiopathic pulmonary fibrosis at a tertiary care hospital.
The retrospective study was conducted at the Aga Khan University Hospital, Karachi, and comprised demographical, clinical and radiological data of patients with interstitial lung disease between October 2016 and October 2017 accessed through the outpatient data registry. Data was compared in terms of characteristics and key features of patients with connective tissue disease-associated interstitial lung disease with those of idiopathic pulmonary fibrosis. Statistical analysis was done using STATA 12.
Of the 184 patients, 52(29.3%) had connective tissue disease-associated interstitial lung disease and 62(35%) had idiopathic pulmonary fibrosis. The most prevalent conditions among connective tissue disease-associated interstitial lung disease patients were rheumatoid arthritis 22(42.3%) and scleroderma 13(25%). Compared to patients with idiopathic pulmonary fibrosis, those with connective tissue disease-associated interstitial lung disease were predominantly younger (p<0.001) and female (p<0.001). History of gastroesophageal reflux disease was also significantly lower in connective tissue disease-associated interstitial lung disease (p=0.05).
Connective tissue disease-associated interstitial lung disease patients were found to be younger and predominantly female compared to patients of idiopathic pulmonary fibrosis.
在一家三级保健医院比较结缔组织病相关性间质性肺疾病与特发性肺纤维化的特征。
该回顾性研究在卡拉奇的阿迦汗大学医院进行，纳入了 2016 年 10 月至 2017 年 10 月通过门诊数据登记系统获取的间质性肺疾病患者的人口统计学、临床和影像学数据。比较了结缔组织病相关性间质性肺疾病患者与特发性肺纤维化患者的特征和关键特征。使用 STATA 12 进行统计分析。
在 184 名患者中，52 名（29.3%）患有结缔组织病相关性间质性肺疾病，62 名（35%）患有特发性肺纤维化。结缔组织病相关性间质性肺疾病患者中最常见的疾病是类风湿关节炎 22 例（42.3%）和硬皮病 13 例（25%）。与特发性肺纤维化患者相比，结缔组织病相关性间质性肺疾病患者主要更年轻（p<0.001）和女性（p<0.001）。结缔组织病相关性间质性肺疾病患者的胃食管反流病病史也明显较低（p=0.05）。
与特发性肺纤维化患者相比，结缔组织病相关性间质性肺疾病患者更年轻，主要为女性。
