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睡眠呼吸障碍患者中快速眼动睡眠相关阻塞性睡眠呼吸暂停(REM相关OSA)的比例:一项横断面研究。

Proportion of rapid eye movement sleep related obstructive sleep apnea (REM related OSA) in patients with sleep disordered breathing: A cross sectional study.

作者信息

Nair Sharada C, Arjun Padmanabhan, Azeez Ameer Kavarathukudy, Nair Sanjeev

机构信息

Department of Respiratory Medicine, Kerala Institute of Medical Sciences, Thiruvananthapuram, Kerala, India.

Department of Respiratory Medicine, Government Medical College, Thiruvananthapuram, Kerala, India.

出版信息

Lung India. 2022 Jan-Feb;39(1):38-43. doi: 10.4103/lungindia.lungindia_64_21.

Abstract

BACKGROUND AND OBJECTIVES

Obstructive sleep apnea (OSA) during rapid eye movement (REM) stage of sleep is gaining importance in recent years. This study was done to determine the proportion of REM-related OSA and its associated polysomnographic features.

METHODS

One hundred forty-two patients were included in the study. REM-related OSA was defined based on previously established broad and strict criteria (REM apnea-hypopnea index [AHI]/non-REM [NREM] AHI ratio ≥2 and REM AHI >5 with NREM AHI <5, respectively), and its association with polysomnographic features was studied using appropriate statistical tools.

RESULTS

The proportion of REM-related OSA in the study was 56.3% and 25.3% as per broad and strict criterion, respectively. The REM-related OSA group had a mean younger age (47.4 ± 13.2 years) as compared to NREM-related OSA group (52.6 ± 15.8 years). Females (34 out of 45; 75.6%) were more likely to have REM-related OSA as compared to males (46 out of 107; 47.4%). Supine AHI, arousal index, oxygen desaturation index, length of the longest event, and the lowest oxygen saturation recorded during sleep had a significant association with REM-related OSA. 74% of patients with overall AHI <5 and 87% patients with overall AHI 5 to 15 satisfied the criteria for REM-related OSA as per broad criterion.

CONCLUSION

REM-related OSA was quite prevalent in the study population (56.3%) and was more common in the mild and moderate severity subgroups of OSA.

摘要

背景与目的

近年来,快速眼动(REM)睡眠期阻塞性睡眠呼吸暂停(OSA)越来越受到关注。本研究旨在确定REM相关OSA的比例及其相关的多导睡眠图特征。

方法

142例患者纳入本研究。REM相关OSA根据先前制定的宽泛和严格标准进行定义(REM呼吸暂停低通气指数[AHI]/非REM[NREM]AHI比值≥2以及REM AHI>5且NREM AHI<5),并使用适当的统计工具研究其与多导睡眠图特征的关联。

结果

根据宽泛和严格标准,本研究中REM相关OSA的比例分别为56.3%和25.3%。与NREM相关OSA组(52.6±15.8岁)相比,REM相关OSA组的平均年龄较轻(47.4±13.2岁)。女性(45例中的34例;75.6%)比男性(107例中的46例;47.4%)更易发生REM相关OSA。仰卧位AHI、觉醒指数、氧饱和度下降指数、最长事件时长以及睡眠期间记录的最低氧饱和度与REM相关OSA有显著关联。总体AHI<5的患者中有74%以及总体AHI为5至15的患者中有87%符合宽泛标准下REM相关OSA的标准。

结论

REM相关OSA在研究人群中相当普遍(56.3%),并且在OSA的轻度和中度严重程度亚组中更为常见。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7717/8926229/8ee65b056d44/LI-39-38-g001.jpg

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