Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine, Thammasat University, 99/209 Paholyotin Road, Khlong Luang, Pathum Thani, Thailand, 12120.
Department of Clinical Epidemiology, Faculty of Medicine, Thammasat University, 99/209 Paholyotin Road, Khlong Luang, Pathum Thani, Thailand, 12120.
Sci Rep. 2022 Jul 5;12(1):11360. doi: 10.1038/s41598-022-13382-z.
Obstructive sleep apnea (OSA) is a common sleep disorder that has been associated with cardiovascular consequences. Rapid eye movement (REM)-related obstructive sleep apnea (OSA) is a subtype of OSA which is characterized by apneas or hypopneas predominately during REM sleep. The factors associated with REM-related OSA are still unclear. We aimed to determine the prevalence and associated characteristics of REM-related OSA in Thai patients. A total of 408 patients' charts were retrospectively reviewed. Demographic and anthropometric characteristics, comorbidities and polysomnographic data were obtained. The patients were divided into two groups: REM-related OSA and non-stage specific OSA. REM-related OSA was defined as an apnea-hypopnea index (AHI) ≥ 5 per hour, with a ratio of REM-AHI to NREM-AHI > 2, and NREM-AHI < 15 per hour. The prevalence of REM-related OSA was 21.6%. AHI and arousal index were both lower in REM-related OSA than in non-stage specific OSA. REM-related OSA was significantly associated with females (OR 2.35, 95% CI 1.25-4.42, p = 0.008), age < 60 years (OR 2.52, 95% CI 1.15-5.55, p = 0.021), and mild OSA (OR 17.46, 95% CI 9.28-32.84, p < 0.001). In conclusion, age < 60 years, female gender, and mild severity of OSA were associated with REM-related OSA.
阻塞性睡眠呼吸暂停（OSA）是一种常见的睡眠障碍，与心血管并发症有关。快速眼动（REM）相关的阻塞性睡眠呼吸暂停（OSA）是 OSA 的一种亚型，其特征是在 REM 睡眠期间主要发生呼吸暂停或呼吸不足。与 REM 相关的 OSA 相关的因素仍不清楚。我们旨在确定泰国患者中 REM 相关 OSA 的患病率和相关特征。回顾性分析了 408 例患者的病历。获取了人口统计学和人体测量学特征、合并症和多导睡眠图数据。患者分为两组：REM 相关 OSA 和非分期特定 OSA。REM 相关 OSA 的定义为每小时呼吸暂停-低通气指数（AHI）≥5，REM-AHI 与 NREM-AHI 的比值>2，且 NREM-AHI<15。REM 相关 OSA 的患病率为 21.6%。REM 相关 OSA 的 AHI 和觉醒指数均低于非分期特定 OSA。REM 相关 OSA 与女性（OR 2.35，95%CI 1.25-4.42，p=0.008）、年龄<60 岁（OR 2.52，95%CI 1.15-5.55，p=0.021）和轻度 OSA（OR 17.46，95%CI 9.28-32.84，p<0.001）显著相关。结论：年龄<60 岁、女性和 OSA 轻度严重程度与 REM 相关 OSA 相关。
