Heldin N E, Karlsson F A, Westermark B
Acta Endocrinol Suppl (Copenh). 1987;281:238-41. doi: 10.1530/acta.0.114s238.
In the present investigation the expression of c-myc in porcine thyroid follicle cells following the incubation with TSH or EGF was studied. EGF did not only have a mitotic effect on thyroid follicles but also increased c-myc mRNA. The increase in c-myc RNA is an early event in EGF stimulated thyroid cells. TSH had no effect on c-myc RNA levels of porcine thyroid cells. EGF-binding and sensitization to the mitotic activity of EGF, however, is increased by TSH. While TSH stimulates cAMP production and functional activity but not growth or c-myc expression of porcine thyroid cells, EGF produces cell division accompanied with c-myc expression.
在本研究中，对用促甲状腺激素（TSH）或表皮生长因子（EGF）孵育后的猪甲状腺滤泡细胞中c-myc的表达进行了研究。EGF不仅对甲状腺滤泡有促有丝分裂作用，还能增加c-myc mRNA。c-myc RNA的增加是EGF刺激甲状腺细胞的早期事件。TSH对猪甲状腺细胞的c-myc RNA水平没有影响。然而，TSH可增加EGF结合以及对EGF有丝分裂活性的敏感性。虽然TSH刺激猪甲状腺细胞的环磷酸腺苷（cAMP）产生和功能活性，但不刺激其生长或c-myc表达，而EGF则产生伴有c-myc表达的细胞分裂。
