Senior Resident, Department of Physical Medicine and Rehabilitation, AIIMS, Patna, Bihar, India.
Additional Professor and Head, Department of Physical Medicine and Rehabilitation, AIIMS, Patna, Bihar, India.
Indian J Public Health. 2021 Oct-Dec;65(4):422-424. doi: 10.4103/ijph.ijph_1716_21.
Guillain-Barré syndrome (GBS) is an acute inflammatory demyelinating disorder of the peripheral nerve. Different variants of GBS can produce a wide array of symptoms among which motor weakness, areflexia without bladder-bowel involvement are commonly encountered. ChAdOx1 nCoV-19 is a recombinant Corona Virus Vaccine and it is incorporated into India's coronavirus disease-2019 (COVID-19) vaccination program. Few rare instances of serious neurological complications have been reported following COVID-19 vaccination. Our case received 2 dose of COVID-19 vaccine. After receiving 1 dose he had rapid onset of ascending paralysis without any sensory and bladder bowel involvement. He received Intra Venous Immuno Globulin and Injection prednisolone for 5 days. Following that his lower limb weakness resolved rapidly but there was no improvement in upper limb weakness. Nerve conduction study showed demyelinating etiology and along with clinical features, it was appeared to be a case of GBS. However, more evidence is needed before establishing the causal relationship between COVID-19 vaccines and GBS.
格林-巴利综合征（GBS）是一种急性炎症性脱髓鞘性周围神经病。GBS 的不同变体可导致广泛的症状，其中运动无力、无膀胱-肠道受累的反射消失较为常见。ChAdOx1 nCoV-19 是一种重组冠状病毒疫苗，已被纳入印度的 2019 年冠状病毒病（COVID-19）疫苗接种计划。COVID-19 疫苗接种后，已报告少数罕见的严重神经系统并发症病例。我们的病例接种了 2 剂 COVID-19 疫苗。在接种第 1 剂后，他迅速出现上升性瘫痪，无任何感觉和膀胱肠道受累。他接受了 5 天的静脉注射免疫球蛋白和泼尼松龙注射治疗。此后，他的下肢无力迅速缓解，但上肢无力无改善。神经传导研究显示脱髓鞘病因，结合临床特征，这似乎是 GBS 病例。然而，在确定 COVID-19 疫苗和 GBS 之间的因果关系之前，还需要更多的证据。
