Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China 100053.
Behav Neurol. 2021 Dec 22;2021:7946252. doi: 10.1155/2021/7946252. eCollection 2021.
A rapidly growing body of evidence supports that neuroinflammation plays a major role in epileptogenesis and disease progression. The capacity to identify pathological neuroinflammation in individuals with epilepsy is a crucial step on the timing of anti-inflammatory intervention and patient selection, which will be challenging aspects in future clinical studies. The discovery of noninvasive biomarkers that are accessible in the blood or molecular neuroimaging would facilitate clinical translation of experimental findings into humans. These innovative and noninvasive approaches have the advantage of monitoring the dynamic changes of neuroinflammation in epilepsy. Here, we will review the available evidence for the measurement of neuroinflammation in patients with epilepsy using noninvasive techniques and critically analyze the major scientific challenges of noninvasive methods. Finally, we propose the potential for use in clinical applications.
越来越多的证据表明，神经炎症在癫痫发生和疾病进展中起主要作用。能够在癫痫患者中识别病理性神经炎症是抗炎干预和患者选择时机的关键步骤，这将是未来临床研究中的挑战方面。发现可在血液或分子神经影像学中获得的无创生物标志物将有助于将实验发现转化为人类的临床应用。这些创新的无创方法具有监测癫痫患者神经炎症动态变化的优势。在这里，我们将回顾使用无创技术测量癫痫患者神经炎症的现有证据，并批判性地分析无创方法的主要科学挑战。最后，我们提出了在临床应用中的潜力。
