Williams Michael, Ahmad Talal, Chin Lawrence S, Richardson Timothy E, Mangla Rajiv, Zain Sultan M, Mirchia Kavya
Pathology, State University of New York Upstate Medical University, Syracuse, USA.
Neurosurgery, State University of New York Upstate Medical University, Syracuse, USA.
Cureus. 2021 Nov 17;13(11):e19678. doi: 10.7759/cureus.19678. eCollection 2021 Nov.
A wide variety of benign and malignant tumors can arise from different structures in the orbital and peri-orbital area, affecting the eye and the optic nerve. This spectrum of tumors includes primary and metastatic carcinomas, lymphomas, melanomas, soft tissue tumors, and primary tumors of the retina, optic disc, and optic nerve. These also extend to relatively rare entities such as solitary fibrous tumor and meningioma of the orbit and optic nerve, which can present with very similar clinical and radiologic features, although the tumor grades, treatment plans, and outcomes can vary widely. In this report, we present two clinical cases of solitary fibrous tumor [central nervous system (CNS) World Health Organization (WHO) grade 2 and 3) and compare their clinical presentation, radiologic and histologic features, treatment, and clinical outcomes to a group of three orbital meningiomas (CNS WHO grade 1 and 2). In the context of these five cases of orbital lesions, we review the current clinical, pathologic, and radiologic literature on orbital tumors, focusing primarily on solitary fibrous tumors and meningiomas, along with an expanded discussion on the diagnostic criteria of both entities, as well as the treatment and prognosis of these lesions.
多种良性和恶性肿瘤可起源于眼眶及眶周区域的不同结构，影响眼睛和视神经。这类肿瘤包括原发性和转移性癌、淋巴瘤、黑色素瘤、软组织肿瘤以及视网膜、视盘和视神经的原发性肿瘤。它们还包括相对罕见的实体，如眼眶和视神经的孤立性纤维瘤和脑膜瘤，尽管肿瘤分级、治疗方案和预后差异很大，但它们可能具有非常相似的临床和放射学特征。在本报告中，我们展示了两例孤立性纤维瘤（世界卫生组织（WHO）中枢神经系统（CNS）2级和3级）的临床病例，并将其临床表现、放射学和组织学特征、治疗及临床结果与一组三例眼眶脑膜瘤（CNS WHO 1级和2级）进行比较。在这五例眼眶病变的背景下，我们回顾了当前关于眼眶肿瘤的临床、病理和放射学文献，主要关注孤立性纤维瘤和脑膜瘤，并对这两种实体的诊断标准以及这些病变的治疗和预后进行了扩展讨论。
