Baroud Sarah, Moustafa Sara, Ibrahim Halah
Internal Medicine, Sheikh Khalifa Medical City, Abu Dhabi, ARE.
Cureus. 2021 Nov 23;13(11):e19846. doi: 10.7759/cureus.19846. eCollection 2021 Nov.
Primary signet-ring cell adenocarcinomas (SRCA) that occur outside the gastrointestinal tract are rare with few cases reported in the literature. They carry a poor prognosis and can be a challenge to diagnose. In this case report, we present the case of a 69-year-old female who presented to our hospital with a large left-sided pleural effusion. The findings seen on histopathology and immunohistochemistry (IHC) staining of the pleural fluid were consistent with primary signet-ring cell adenocarcinoma of the lung, and further investigations excluded a secondary source of malignancy. To the best of our knowledge, this is the first reported case of pleural effusion without an underlying lung mass diagnosed as primary signet-ring cell adenocarcinoma of the lung. Given how rare primary signet-ring cell adenocarcinoma of the lung is, it is important for physicians to carry out a comprehensive diagnostic workup to differentiate between primary and metastatic signet-ring cell adenocarcinoma as this will determine prognosis and treatment.
发生在胃肠道外的原发性印戒细胞腺癌（SRCA）较为罕见，文献报道的病例很少。它们预后较差，诊断可能具有挑战性。在本病例报告中，我们介绍了一名69岁女性，她因左侧大量胸腔积液前来我院就诊。胸腔积液的组织病理学和免疫组织化学（IHC）染色结果与原发性肺印戒细胞腺癌一致，进一步检查排除了恶性肿瘤的继发性来源。据我们所知，这是首例报道的无潜在肺部肿块而被诊断为原发性肺印戒细胞腺癌的胸腔积液病例。鉴于原发性肺印戒细胞腺癌非常罕见，医生进行全面的诊断检查以区分原发性和转移性印戒细胞腺癌很重要，因为这将决定预后和治疗。
