Udomittipong Kanokporn, Thabungkan Teerapat, Nimmannit Akarin, Tovichien Prakarn, Charoensitisup Pawinee, Mahoran Khunphon
Division of Pulmonology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Division of Clinical Epidemiology, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Front Pediatr. 2021 Dec 15;9:789290. doi: 10.3389/fped.2021.789290. eCollection 2021.
We aimed to determine the obesity indices that affect 6-min walk test (6-MWT) distance in children and adolescents with obesity and to compare the 6-MWT distance of obese subjects with that of normal-weight subjects. Obese children and adolescents aged 8-15 years and normal-weight age- and gender-matched controls were enrolled. All participants performed the 6-MWT; respiratory muscle strength (RMS), including maximal inspiratory pressure and maximal expiratory pressure; and spirometry. Data between groups were compared. In the obesity group, correlation between obesity indices and pulmonary function testing (6-MWT, RMS, and spirometry) was analyzed. The study included 37 obese and 31 normal-weight participants. The following parameters were all significantly lower in the obesity group than in the normal-weight group: 6-MWT distance (472.1 ± 66.2 vs. 513.7 ± 72.9 m; = 0.02), forced expiratory volume in one second/forced vital capacity (FEV/FVC) (85.3 ± 6.7 vs. 90.8 ± 4.5%; < 0.001), forced expiratory flow rate within 25-75% of vital capacity (FEF) (89.8 ± 23.1 vs. 100.4 ± 17.3 %predicted; = 0.04), and peak expiratory flow (PEF) (81.2 ± 15 vs. 92.5 ± 19.6 %predicted; = 0.01). The obesity indices that significantly correlated with 6-MWT distance in obese children and adolescents were waist circumference-to-height ratio (WC/Ht) ( = -0.51; = 0.001), waist circumference ( = -0.39; = 0.002), body mass index (BMI) ( = -0.36; = 0.03), and chest circumference ( = -0.35; = 0.04). WC/Ht was the only independent predictor of 6-MWT distance by multiple linear regression. Children and adolescents with obesity had a significantly shorter 6-MWT distance compared with normal-weight subjects. WC/Ht was the only independent predictor of 6-MWT distance in the obesity group.
我们旨在确定影响肥胖儿童和青少年6分钟步行试验(6-MWT)距离的肥胖指数,并比较肥胖受试者与正常体重受试者的6-MWT距离。纳入了8至15岁的肥胖儿童和青少年以及年龄和性别匹配的正常体重对照者。所有参与者均进行了6-MWT;呼吸肌力量(RMS),包括最大吸气压力和最大呼气压力;以及肺功能测定。比较了组间数据。在肥胖组中,分析了肥胖指数与肺功能测试(6-MWT、RMS和肺功能测定)之间的相关性。该研究包括37名肥胖参与者和31名正常体重参与者。肥胖组的以下参数均显著低于正常体重组:6-MWT距离(472.1±66.2对513.7±72.9米;P=0.02)、一秒用力呼气量/用力肺活量(FEV/FVC)(85.3±6.7对90.8±4.5%;P<0.001)、肺活量25-75%范围内的用力呼气流量(FEF)(89.8±23.1对100.4±17.3%预测值;P=0.04)以及呼气峰值流量(PEF)(81.2±15对92.5±19.6%预测值;P=0.01)。与肥胖儿童和青少年的6-MWT距离显著相关的肥胖指数为腰围身高比(WC/Ht)(r=-0.51;P=0.001)、腰围(r=-0.39;P=0.002)、体重指数(BMI)(r=-0.36;P=0.03)和胸围(r=-0.35;P=0.04)。通过多元线性回归分析,WC/Ht是6-MWT距离的唯一独立预测因素。与正常体重受试者相比,肥胖儿童和青少年的6-MWT距离显著缩短。WC/Ht是肥胖组6-MWT距离的唯一独立预测因素。