Centers for Disease Control and Prevention, Atlanta, GA, United States.
New Mexico Department of Health, Santa Fe, NM, United States.
Front Public Health. 2021 Dec 16;9:744179. doi: 10.3389/fpubh.2021.744179. eCollection 2021.
Outbreaks of wound botulism are rare, but clinicians and health departments should maintain suspicion for signs, symptoms, and risk factors of wound botulism among persons who inject drugs in order to initiate treatment quickly. This report describes an outbreak of three wound botulism cases among persons in two adjacent counties who injected drugs. Provisional information about these cases was previously published in the CDC National Botulism Surveillance Summary. All three cases in this outbreak were laboratory-confirmed, including one case with detection of botulinum toxin type A in a wound culture sample taken 43 days after last possible heroin exposure. Findings highlight the delay in diagnosis which led to prolonged hospitalization and the persistence of botulinum toxin in one patient.
伤口肉毒杆菌病的暴发较为罕见，但临床医生和卫生部门应保持警惕，注意有吸毒史人群中伤口肉毒杆菌病的体征、症状和危险因素，以便尽快开始治疗。本报告描述了两相邻县因注射吸毒而发生的三例伤口肉毒杆菌病暴发。这些病例的初步信息先前曾在疾病预防控制中心国家肉毒杆菌病监测总结中发表过。此次暴发中的所有三例均经实验室确诊，包括一例在最后一次可能接触海洛因后 43 天从伤口培养样本中检测到 A 型肉毒毒素的病例。研究结果强调了诊断延迟导致住院时间延长以及一位患者体内肉毒毒素持续存在的问题。
