School of Pharmacy, Anhui Medical University, Hefei, Anhui 230032, China.
School of Dentistry, Anhui Medical University, Hefei, Anhui 230032, China.
J Diabetes Res. 2021 Dec 24;2021:1254968. doi: 10.1155/2021/1254968. eCollection 2021.
Diabetes is one of the common chronic diseases in which susceptibility is determined by a combination of genetic and environmental factors, and more than 90% of diabetic patients are diabetes mellitus type 2 (T2DM). The existing studies on the association between CDKAL1 rs10946398 gene polymorphism and susceptibility to type 2 diabetes are inconsistent across populations.
We aim to explore the association between CDKAL1 rs10946398 gene polymorphism and susceptibility to type 2 diabetes in different populations.
We examined all studies before June 12, 2021, that associated CDKAL1 rs10946398 with T2DM. Heterogeneity was assessed by meta-analysis of allelic inheritance models (A vs. C), dominant inheritance models (AA vs. AC+CC), and recessive inheritance model (AA+AC vs. CC); was used to assess the heterogeneity (if < 50%, the fixed-effects model was used; if ≥ 50%, the random-effects model was used for data consolidation); correlation was judged by a forest map; potential publication bias was tested by the Egger test ( > 0.05 indicates that there is no publication bias).
Fourteen data totaling 30288 subjects, including 19272 controls and 11016 patients with T2DM, met our inclusion criteria. In the Asian population, the differences were statistically significant ( < 0.01) for dominant genetic model (OR = 0.75, 95%CI = 0.64-0.88, = 0.0003). But the allelic effect model (OR = 0.87, 95%CI = 0.75-1.02, = 0.08) and the recessive genetic model (OR = 0.85, 95%CI = 0.66-1.10, = 0.23) were not statistically significant ( > 0.01). In the non-Asian population, the differences were statistically significant ( < 0.01) for the allelic effect model (OR = 0.83, 95%CI = 0.77-0.88, < 0.00001), the dominant model (OR = 0.79, 95%CI = 0.72-0.87, < 0.00001), and the recessive model (OR = 0.78, 95%CI = 0.70-0.87, < 0.0001).
In this study, CDKAL1 RS10946398 was positively associated with T2DM, but the association was different in Asian populations.
糖尿病是一种常见的慢性疾病，其易感性由遗传和环境因素共同决定，超过 90%的糖尿病患者为 2 型糖尿病（T2DM）。目前关于 CDKAL1 rs10946398 基因多态性与 2 型糖尿病易感性的关联在不同人群中的研究结果并不一致。
旨在探讨 CDKAL1 rs10946398 基因多态性与不同人群 2 型糖尿病易感性的关系。
检索 2021 年 6 月 12 日前与 CDKAL1 rs10946398 与 T2DM 相关的所有研究。采用等位基因遗传模型（A 对 C）、显性遗传模型（AA 对 AC+CC）和隐性遗传模型（AA+AC 对 CC）进行荟萃分析评估异质性；用 Q 检验（ < 0.05 采用固定效应模型， > 0.05 采用随机效应模型）评估异质性；用森林图判断相关性；用 Egger 检验（ > 0.05 表示无发表偏倚）检验潜在的发表偏倚。
共纳入 14 项研究，总计 30288 例受试者，包括 19272 例对照和 11016 例 T2DM 患者。在亚洲人群中，显性遗传模型（OR=0.75，95%CI=0.64-0.88， =0.0003）差异有统计学意义。但等位基因效应模型（OR=0.87，95%CI=0.75-1.02， =0.08）和隐性遗传模型（OR=0.85，95%CI=0.66-1.10， =0.23）差异无统计学意义（ > 0.01）。在非亚洲人群中，等位基因效应模型（OR=0.83，95%CI=0.77-0.88， < 0.00001）、显性模型（OR=0.79，95%CI=0.72-0.87， < 0.00001）和隐性模型（OR=0.78，95%CI=0.70-0.87， < 0.0001）差异均有统计学意义。
本研究表明，CDKAL1 RS10946398 与 T2DM 呈正相关，但在亚洲人群中这种关联存在差异。
