Rojas Lievano Jorge, Rotman Dani, Shields Maegan N, Morrey Mark E, Sanchez-Sotelo Joaquin, Shukla Dave R, Olson Tammy S, Vaichinger Anthony M, Fitzsimmons James S, O'Driscoll Shawn W
Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, U.S.A.
Arthrosc Sports Med Rehabil. 2021 Nov 17;3(6):e1873-e1882. doi: 10.1016/j.asmr.2021.09.002. eCollection 2021 Dec.
To generate an evidence-based opioid-prescribing guideline by assessing the pattern of total opioid consumption and the factors that may predict opioid consumption following arthroscopic release of elbow contracture and to investigate whether the use of continuous passive motion (CPM), as compared to physical therapy (PT), was associated with a decrease in pain and opioid consumption after arthroscopic release of elbow contracture.
Data collected from a randomized controlled trial that compared continuous passive motion (CPM) ( = 24) to physical therapy (PT) ( = 27) following arthroscopic release of elbow contracture was analyzed for opioid use. Fifty-one participants recorded their daily opioid consumption in a postoperative diary for 90 days. Multivariate analysis was performed to identify factors associated with opioid use. Recommended quantities for postoperative prescription were generated using the 50th percentile for patients without and the 75th percentile for patients with factors associated with higher opioid use.
The median total opioid prescription was 437.5-mg morphine milligram equivalents (MMEs) (58 pills of 5 mg oxycodone) and the median total opioid consumption was 75 MMEs (10 pills of 5-mg oxycodone). Twenty-two percent of patients took no opioid medication, 53% took ≤10 pills, 69% took ≤20 pills and 75% took ≤30 pills. Predictors of higher opioid use were preoperative opioid use, age <60 years and inflammatory arthritis. The total opioid consumption appeared similar between the CPM and the PT group. Seventy-five percent of patient's home opioid requirements would be satisfied using the following guideline: Patients undergoing contracture release for osteoarthritis or post-traumatic contracture should be given a prescription for 10 pills of 5 mg oxycodone or its equivalent at discharge. Patients with inflammatory conditions or those taking preoperative opioids should be prescribed 30 pills of 5 mg oxycodone or its equivalent.
This study suggests that most patients undergoing arthroscopic release of elbow contracture use relatively few opioid pills after surgery. Use of an evidence-based guideline could decrease opioid prescriptions substantially, while still effectively treating patients' pain.
通过评估肘关节挛缩关节镜松解术后阿片类药物的总使用模式以及可能预测阿片类药物使用的因素,制定基于证据的阿片类药物处方指南,并研究与物理治疗(PT)相比,持续被动运动(CPM)的使用是否与肘关节挛缩关节镜松解术后疼痛减轻和阿片类药物使用减少相关。
对一项随机对照试验收集的数据进行分析,该试验比较了肘关节挛缩关节镜松解术后持续被动运动(CPM)组(n = 24)和物理治疗(PT)组(n = 27)的阿片类药物使用情况。51名参与者在术后日记中记录了90天内每日的阿片类药物使用量。进行多变量分析以确定与阿片类药物使用相关的因素。根据未出现相关因素患者的第50百分位数以及出现与较高阿片类药物使用相关因素患者的第75百分位数,得出术后处方的推荐剂量。
阿片类药物总处方量的中位数为437.5毫克吗啡毫克当量(MME)(相当于58片5毫克羟考酮),阿片类药物总使用量的中位数为75 MME(相当于10片5毫克羟考酮)。22%的患者未服用阿片类药物,53%的患者服用≤10片,69%的患者服用≤20片,75%的患者服用≤30片。较高阿片类药物使用的预测因素为术前使用阿片类药物、年龄<60岁和炎性关节炎。CPM组和PT组的阿片类药物总使用量似乎相似。使用以下指南可满足75%患者的家庭阿片类药物需求:因骨关节炎或创伤后挛缩接受挛缩松解术的患者,出院时应开具10片5毫克羟考酮或其等效药物的处方。患有炎性疾病或术前服用阿片类药物的患者,应开具30片5毫克羟考酮或其等效药物的处方。
本研究表明,大多数接受肘关节挛缩关节镜松解术的患者术后使用的阿片类药物相对较少。使用基于证据的指南可大幅减少阿片类药物处方,同时仍能有效治疗患者的疼痛。