Elevated Blood Pressure (≥120/80 mmHg) Is Associated with Elevated Serum Plasminogen Activator Inhibitor-1, Low Birth Weight, and Family History of Diabetes in Young Normal Weight Japanese Women.

We examined whether elevated blood pressure (BP) (≥120/80 mmHg) was associated with several anthropometric, metabolic, and clinical variables, including the family history of type 2 diabetes (FHD) and low birth weight, in young normal weight Japanese women. BP, body composition, and fasting glucose, insulin, lipids, lipoproteins, apolipoproteins, and adipokines were measured in 332 young Japanese women. They received a questionnaire on birth weight and FHD. The prevalence of low birth weight was 2.4% and that of positive FHD was 22.9%. Homeostasis model assessment-insulin resistance averaged <1.5 and did not differ cross-sectionally between 32 women with elevated BP and 300 women with normal BP although mean body mass index was higher in the former than in the latter (21.7 ± 2.9 kg/m vs. 20.8 ± 2.2 kg/m,  = 0.02). Women with elevated BP had higher fat mass index ( = 0.02) and trunk fat percentage ( = 0.04). They had lower high-density lipoprotein (HDL) cholesterol and apolipoprotein A1 (both  = 0.01) while fasting triglycerides and apolipoprotein B did not differ. In addition, they had higher plasminogen activator inhibitor-1 (PAI-1) ( = 0.001). Furthermore, the prevalence of low birth weight (9.4% vs. 1.7%,  = 0.03) and positive FHD (40.6% vs. 20.0%,  = 0.01) was higher in women with elevated BP. Multivariable logistic regression analyses revealed that elevated BP was independently associated with PAI-1 [odds ratio (OR); 1.05, 95% confidence interval (CI): 1.02-1.08,  = 0.001], low birth weight (OR: 12.3, 95% CI: 2.3-67.3,  = 0.04), and FHD (OR: 3.0, 95% CI: 1.3-7.9,  = 0.01). Elevated BP was associated with positive FHD, low birth weight, and elevated serum PAI-1 in young normal weight Japanese women.