Open Research Center for Studying of Lifestyle-Related Diseases, Mukogawa Women's University, Nishinomiya, Hyogo, Japan.
Department of Health, Sports, and Nutrition, Faculty of Health and Welfare, Kobe Women's University, Kobe, Hyogo, Japan.
J Diabetes Res. 2022 Jan 22;2022:7153238. doi: 10.1155/2022/7153238. eCollection 2022.
Adipose tissue (AT) expandability may be facilitated by adiponectin and suppressed by orosomucoid, and reduced AT expandability may be associated with first-degree relatives of type 2 diabetes. We tested the hypothesis that orosomucoid may be associated not only with adiponectin and adipose tissue insulin resistance but also with a family history of type 2 diabetes (FHD). Anthropometric and metabolic variables, adipokines, and measures of inflammatory and insulin resistance were cross-sectionally investigated in 153 young normal weight Japanese women. Stepwise multivariate linear regression analyses were used to identify the most important determinants of orosomucoid.
Orosomucoid was higher in women with positive ( = 57) compared to women with negative FHD and was associated positively with FHD (both = 0.01). Orosomucoid also showed positive associations with fasting glucose ( < 0.001), free fatty acids ( = 0.001), and HbA1c ( = 0.007), whereas there was no association with fasting insulin and serum lipids. In addition, orosomucoid was associated inversely with adiponectin ( = 0.02) and positively with adipose tissue-insulin resistance index (AT-IR, the product of fasting insulin and free fatty acids; = 0.001) but not with homeostasis model assessment-insulin resistance, leptin, and high-sensitivity C-reactive protein. In multivariate analyses, AT-IR (standardized , 0.22; = 0.003), serum adiponectin (standardized , -0.163; = 0.032), FHD+ (standardized , 0.178; = 0.029), and HbA1c (standardized , 0.213; = 0.005) emerged as independent determinants of orosomucoid and explained 15.2% of its variability.
These results are the first to demonstrate that orosomucoid is associated not only with adipose tissue-insulin resistance and adiponectin but also with FHD.
脂肪组织（AT）的可扩展性可能受到脂联素的促进，受到乳清蛋白的抑制，而 AT 的可扩展性降低可能与 2 型糖尿病的一级亲属有关。我们检验了这样一个假设，即乳清蛋白不仅与脂联素和脂肪组织胰岛素抵抗有关，而且与 2 型糖尿病的家族史（FHD）有关。我们在 153 名年轻的日本正常体重女性中进行了横断面研究，检测了人体测量和代谢变量、 adipokines 以及炎症和胰岛素抵抗的测量结果。使用逐步多元线性回归分析来确定乳清蛋白的最重要决定因素。
与 FHD 阴性的女性（n=57）相比，FHD 阳性的女性（n=57）的乳清蛋白水平更高（均为 P=0.01）。乳清蛋白与空腹血糖（P<0.001）、游离脂肪酸（P=0.001）和 HbA1c（P=0.007）呈正相关，而与空腹胰岛素和血清脂质无关。此外，乳清蛋白与脂联素呈负相关（P=0.02），与脂肪组织胰岛素抵抗指数（AT-IR，空腹胰岛素和游离脂肪酸的乘积；P=0.001）呈正相关，但与稳态模型评估-胰岛素抵抗、瘦素和高敏 C 反应蛋白无关。在多元分析中，AT-IR（标准化β，0.22；P=0.003）、血清脂联素（标准化β，-0.163；P=0.032）、FHD+（标准化β，0.178；P=0.029）和 HbA1c（标准化β，0.213；P=0.005）是乳清蛋白的独立决定因素，解释了乳清蛋白变异性的 15.2%。
这些结果首次表明，乳清蛋白不仅与脂肪组织胰岛素抵抗和脂联素有关，而且与 FHD 有关。
