Institute of Bismuth Science, University of Shanghai for Science and Technology, Shanghai, China.
Department of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Am J Mens Health. 2022 Jan-Feb;16(1):15579883211067084. doi: 10.1177/15579883211067084.
The objective of the study was to assess the association between changes in plasma follicle-stimulating hormone (FSH) and the potential effect on idiopathic pulmonary arterial hypertension (IPAH) in male patients. A total of 116 male patients with IPAH and 53 healthy controls were included from XX Hospital. Plasma FSH concentration was assessed in all participants. Receiver operating characteristic curves were used to assess the mortality risk. Kaplan-Meier curve and Cox regression analyses were used to predict the value of FSH on the survival rate of male IPAH patients. The plasma FSH concentration in the IPAH group was significantly higher than that in the control group ( = .017). Nonsurvivors had significantly higher levels of FSH than survivors ( < .0001). FSH levels were positively correlated with World Health Organization Functional Class, mean pulmonary artery pressure, and pulmonary vascular resistance (PVR; = .023, < .0001, and < .0001, respectively) and negatively correlated with 6-min walk distance (6MWD) and cardiac output (CO; = .004 and = .010). Cox regression model analysis showed that the levels of FSH were also the independent factors of mortality in male IPAH patients ( < .0001). The IPAH patients with higher FSH levels had higher PVR, lower 6MWD, CO, and a lower survival rate ( = .042, = .003, = .029, and < .0001, respectively). Therefore, we identified that increased FSH levels were associated with disease severity in male patients with IPAH and independently predicted risk of disease and poor survival rate.
本研究旨在评估血浆卵泡刺激素（FSH）变化与男性特发性肺动脉高压（IPAH）潜在影响之间的关系。从 XX 医院共纳入 116 例 IPAH 男性患者和 53 例健康对照者。所有参与者均评估血浆 FSH 浓度。采用受试者工作特征曲线评估死亡率风险。Kaplan-Meier 曲线和 Cox 回归分析用于预测 FSH 对男性 IPAH 患者生存率的价值。IPAH 组的血浆 FSH 浓度明显高于对照组（=.017）。非幸存者的 FSH 水平明显高于幸存者（<.0001）。FSH 水平与世界卫生组织功能分级、平均肺动脉压和肺血管阻力（PVR；=.023、<.0001 和<.0001）呈正相关，与 6 分钟步行距离（6MWD）和心输出量（CO；=.004 和=.010）呈负相关。Cox 回归模型分析表明，FSH 水平也是男性 IPAH 患者死亡的独立因素（<.0001）。FSH 水平较高的 IPAH 患者的 PVR 较高，6MWD、CO 较低，生存率较低（=.042、=.003、=.029 和<.0001）。因此，我们发现 IPAH 男性患者中 FSH 水平升高与疾病严重程度相关，独立预测疾病风险和生存率降低。
